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Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

We recently identified meclizine, an over-the-counter drug, as an inhibitor of mitochondrial respiration. Curiously, meclizine blunted respiration in intact cells but not in isolated mitochondria, suggesting an unorthodox mechanism. Using a metabolic profiling approach, we now show that treatment wi...

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Detalles Bibliográficos
Autores principales:	Gohil, Vishal M., Zhu, Lin, Baker, Charli D., Cracan, Valentin, Yaseen, Abbas, Jain, Mohit, Clish, Clary B., Brookes, Paul S., Bakovic, Marica, Mootha, Vamsi K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Bioenergetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853286/ https://www.ncbi.nlm.nih.gov/pubmed/24142790 http://dx.doi.org/10.1074/jbc.M113.489237

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