Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our f...

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Detalles Bibliográficos
Autores principales: Braidy, Nady, Gai, Wei-Ping, Xu, Ying Hua, Sachdev, Perminder, Guillemin, Gilles J, Jiang, Xing-Mai, Ballard, J William O, Horan, Martin P, Fang, Zhi Ming, Chong, Beng H, Chan, Daniel Kam Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853407/
https://www.ncbi.nlm.nih.gov/pubmed/24093918
http://dx.doi.org/10.1186/2047-9158-2-20

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