Cargando…

Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients

BACKGROUND: Downstream activation through receptor tyrosine kinases (RTKs) plays important roles in carcinogenesis. In this study, we assessed the clinical involvement of Axl, an RTK, and its ligand, Gas6, in surgically treated lung adenocarcinoma. METHODS: Axl and Gas6 mRNA and protein expression l...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishikawa, Masashi, Sonobe, Makoto, Nakayama, Ei, Kobayashi, Masashi, Kikuchi, Ryutaro, Kitamura, Jiro, Imamura, Naoto, Date, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853411/
https://www.ncbi.nlm.nih.gov/pubmed/23242819
http://dx.doi.org/10.1245/s10434-012-2795-3
_version_ 1782294630165905408
author Ishikawa, Masashi
Sonobe, Makoto
Nakayama, Ei
Kobayashi, Masashi
Kikuchi, Ryutaro
Kitamura, Jiro
Imamura, Naoto
Date, Hiroshi
author_facet Ishikawa, Masashi
Sonobe, Makoto
Nakayama, Ei
Kobayashi, Masashi
Kikuchi, Ryutaro
Kitamura, Jiro
Imamura, Naoto
Date, Hiroshi
author_sort Ishikawa, Masashi
collection PubMed
description BACKGROUND: Downstream activation through receptor tyrosine kinases (RTKs) plays important roles in carcinogenesis. In this study, we assessed the clinical involvement of Axl, an RTK, and its ligand, Gas6, in surgically treated lung adenocarcinoma. METHODS: Axl and Gas6 mRNA and protein expression levels were quantified using quantitative real-time polymerase chain reaction and immunohistochemistry, respectively, in completely resected lung adenocarcinoma tissues (n = 88) and were evaluated for correlation with clinicopathologic features and patient survival. RESULTS: Higher expressions of Axl mRNA/protein and Gas6 protein were significantly related to worse clinicopathological features and prognosis (5-year overall survival rates: Axl mRNA low: 72.3 %, high: 49.7 %, P = 0.047; Axl protein low: 77.5 %, high: 38.6 %, P < 0.001; and Gas6 protein low: 70.5 %, high: 48 %, P = 0.042). On the contrary, higher Gas6 mRNA expression was related to better clinicopathological features and prognosis (5-year overall survival rates: Gas6 mRNA low: 59.2 %, high: 81.8 %, P = 0.054). Multivariate analysis suggests that high Axl mRNA expression may be an independent factor for poor patient prognosis (P = 0.04). CONCLUSIONS: In lung adenocarcinoma, Axl and Gas6 expression levels were associated with tumor advancement and patient survival, thus rendering them as reliable biomarkers and potential targets for treatment of lung adenocarcinoma.
format Online
Article
Text
id pubmed-3853411
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-38534112013-12-09 Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients Ishikawa, Masashi Sonobe, Makoto Nakayama, Ei Kobayashi, Masashi Kikuchi, Ryutaro Kitamura, Jiro Imamura, Naoto Date, Hiroshi Ann Surg Oncol Translational Research and Biomarkers BACKGROUND: Downstream activation through receptor tyrosine kinases (RTKs) plays important roles in carcinogenesis. In this study, we assessed the clinical involvement of Axl, an RTK, and its ligand, Gas6, in surgically treated lung adenocarcinoma. METHODS: Axl and Gas6 mRNA and protein expression levels were quantified using quantitative real-time polymerase chain reaction and immunohistochemistry, respectively, in completely resected lung adenocarcinoma tissues (n = 88) and were evaluated for correlation with clinicopathologic features and patient survival. RESULTS: Higher expressions of Axl mRNA/protein and Gas6 protein were significantly related to worse clinicopathological features and prognosis (5-year overall survival rates: Axl mRNA low: 72.3 %, high: 49.7 %, P = 0.047; Axl protein low: 77.5 %, high: 38.6 %, P < 0.001; and Gas6 protein low: 70.5 %, high: 48 %, P = 0.042). On the contrary, higher Gas6 mRNA expression was related to better clinicopathological features and prognosis (5-year overall survival rates: Gas6 mRNA low: 59.2 %, high: 81.8 %, P = 0.054). Multivariate analysis suggests that high Axl mRNA expression may be an independent factor for poor patient prognosis (P = 0.04). CONCLUSIONS: In lung adenocarcinoma, Axl and Gas6 expression levels were associated with tumor advancement and patient survival, thus rendering them as reliable biomarkers and potential targets for treatment of lung adenocarcinoma. Springer US 2012-12-16 2013 /pmc/articles/PMC3853411/ /pubmed/23242819 http://dx.doi.org/10.1245/s10434-012-2795-3 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Translational Research and Biomarkers
Ishikawa, Masashi
Sonobe, Makoto
Nakayama, Ei
Kobayashi, Masashi
Kikuchi, Ryutaro
Kitamura, Jiro
Imamura, Naoto
Date, Hiroshi
Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients
title Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients
title_full Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients
title_fullStr Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients
title_full_unstemmed Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients
title_short Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients
title_sort higher expression of receptor tyrosine kinase axl, and differential expression of its ligand, gas6, predict poor survival in lung adenocarcinoma patients
topic Translational Research and Biomarkers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853411/
https://www.ncbi.nlm.nih.gov/pubmed/23242819
http://dx.doi.org/10.1245/s10434-012-2795-3
work_keys_str_mv AT ishikawamasashi higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients
AT sonobemakoto higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients
AT nakayamaei higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients
AT kobayashimasashi higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients
AT kikuchiryutaro higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients
AT kitamurajiro higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients
AT imamuranaoto higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients
AT datehiroshi higherexpressionofreceptortyrosinekinaseaxlanddifferentialexpressionofitsligandgas6predictpoorsurvivalinlungadenocarcinomapatients