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Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report
Primary neuroendocrine carcinoma (PNEC) of breast was an unknown pathologic entity till recently due its rare incidence and lack of definitive criteria for diagnosis. We present a case of PNEC of breast in a middle aged lady. A 34 years lady presented with a breast lump since 1 month, who underwent...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853605/ https://www.ncbi.nlm.nih.gov/pubmed/24349846 http://dx.doi.org/10.4103/2141-9248.121218 |
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author | Murthy, VS Geethamala, K Kumar, BD Sudharao, M |
author_facet | Murthy, VS Geethamala, K Kumar, BD Sudharao, M |
author_sort | Murthy, VS |
collection | PubMed |
description | Primary neuroendocrine carcinoma (PNEC) of breast was an unknown pathologic entity till recently due its rare incidence and lack of definitive criteria for diagnosis. We present a case of PNEC of breast in a middle aged lady. A 34 years lady presented with a breast lump since 1 month, who underwent modified radical mastectomy with axillary clearance. Histopathological diagnoses were infiltrating ductal carcinoma-neuroendocrine (NE) type. Immunohistochemistry showed estrogen, progesterone positivity and NE markers positivity in more than 50% of tumor cells for chromogranin, synaptophysin, neuron specific enolase. On further investigation by whole body computed tomography and magnetic resonance imaging revealed no extra mammary primary tumor. Hence the diagnosis of PNEC of breast was confirmed. Patient received chemo and hormonal therapy and doing well after 6 months of follow up. |
format | Online Article Text |
id | pubmed-3853605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38536052013-12-16 Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report Murthy, VS Geethamala, K Kumar, BD Sudharao, M Ann Med Health Sci Res Case Report Primary neuroendocrine carcinoma (PNEC) of breast was an unknown pathologic entity till recently due its rare incidence and lack of definitive criteria for diagnosis. We present a case of PNEC of breast in a middle aged lady. A 34 years lady presented with a breast lump since 1 month, who underwent modified radical mastectomy with axillary clearance. Histopathological diagnoses were infiltrating ductal carcinoma-neuroendocrine (NE) type. Immunohistochemistry showed estrogen, progesterone positivity and NE markers positivity in more than 50% of tumor cells for chromogranin, synaptophysin, neuron specific enolase. On further investigation by whole body computed tomography and magnetic resonance imaging revealed no extra mammary primary tumor. Hence the diagnosis of PNEC of breast was confirmed. Patient received chemo and hormonal therapy and doing well after 6 months of follow up. Medknow Publications & Media Pvt Ltd 2013-11 /pmc/articles/PMC3853605/ /pubmed/24349846 http://dx.doi.org/10.4103/2141-9248.121218 Text en Copyright: © Annals of Medical and Health Sciences Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Murthy, VS Geethamala, K Kumar, BD Sudharao, M Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report |
title | Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report |
title_full | Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report |
title_fullStr | Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report |
title_full_unstemmed | Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report |
title_short | Primary Neuroendocrine Carcinoma of Breast: A Rare Case Report |
title_sort | primary neuroendocrine carcinoma of breast: a rare case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853605/ https://www.ncbi.nlm.nih.gov/pubmed/24349846 http://dx.doi.org/10.4103/2141-9248.121218 |
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