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Chlorinated Didemnins from the Tunicate Trididemnum solidum

Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectrosc...

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Detalles Bibliográficos
Autores principales: Ankisetty, Sridevi, Khan, Shabana I., Avula, Bharathi, Gochfeld, Deborah, Khan, Ikhlas A., Slattery, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853740/
https://www.ncbi.nlm.nih.gov/pubmed/24284424
http://dx.doi.org/10.3390/md11114478
Descripción
Sumario:Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1–4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.