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Chlorinated Didemnins from the Tunicate Trididemnum solidum
Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectrosc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853740/ https://www.ncbi.nlm.nih.gov/pubmed/24284424 http://dx.doi.org/10.3390/md11114478 |
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author | Ankisetty, Sridevi Khan, Shabana I. Avula, Bharathi Gochfeld, Deborah Khan, Ikhlas A. Slattery, Marc |
author_facet | Ankisetty, Sridevi Khan, Shabana I. Avula, Bharathi Gochfeld, Deborah Khan, Ikhlas A. Slattery, Marc |
author_sort | Ankisetty, Sridevi |
collection | PubMed |
description | Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1–4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines. |
format | Online Article Text |
id | pubmed-3853740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38537402013-12-06 Chlorinated Didemnins from the Tunicate Trididemnum solidum Ankisetty, Sridevi Khan, Shabana I. Avula, Bharathi Gochfeld, Deborah Khan, Ikhlas A. Slattery, Marc Mar Drugs Article Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1–4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines. MDPI 2013-11-11 /pmc/articles/PMC3853740/ /pubmed/24284424 http://dx.doi.org/10.3390/md11114478 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Ankisetty, Sridevi Khan, Shabana I. Avula, Bharathi Gochfeld, Deborah Khan, Ikhlas A. Slattery, Marc Chlorinated Didemnins from the Tunicate Trididemnum solidum |
title | Chlorinated Didemnins from the Tunicate Trididemnum solidum |
title_full | Chlorinated Didemnins from the Tunicate Trididemnum solidum |
title_fullStr | Chlorinated Didemnins from the Tunicate Trididemnum solidum |
title_full_unstemmed | Chlorinated Didemnins from the Tunicate Trididemnum solidum |
title_short | Chlorinated Didemnins from the Tunicate Trididemnum solidum |
title_sort | chlorinated didemnins from the tunicate trididemnum solidum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853740/ https://www.ncbi.nlm.nih.gov/pubmed/24284424 http://dx.doi.org/10.3390/md11114478 |
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