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Chlorinated Didemnins from the Tunicate Trididemnum solidum

Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectrosc...

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Autores principales: Ankisetty, Sridevi, Khan, Shabana I., Avula, Bharathi, Gochfeld, Deborah, Khan, Ikhlas A., Slattery, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853740/
https://www.ncbi.nlm.nih.gov/pubmed/24284424
http://dx.doi.org/10.3390/md11114478
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author Ankisetty, Sridevi
Khan, Shabana I.
Avula, Bharathi
Gochfeld, Deborah
Khan, Ikhlas A.
Slattery, Marc
author_facet Ankisetty, Sridevi
Khan, Shabana I.
Avula, Bharathi
Gochfeld, Deborah
Khan, Ikhlas A.
Slattery, Marc
author_sort Ankisetty, Sridevi
collection PubMed
description Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1–4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines.
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spelling pubmed-38537402013-12-06 Chlorinated Didemnins from the Tunicate Trididemnum solidum Ankisetty, Sridevi Khan, Shabana I. Avula, Bharathi Gochfeld, Deborah Khan, Ikhlas A. Slattery, Marc Mar Drugs Article Chemical investigation of the tunicate Trididemnum solidum resulted in the isolation of two new chlorinated compounds belonging to the didemnin class, along with two known compounds didemnin A and didemnin B. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. The isolated compounds 1–4 were tested for their anti-inflammatory activity using in vitro assays for inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB) activity. The anti-cell proliferative activity of the above compounds was also evaluated against four solid tumor cell lines. MDPI 2013-11-11 /pmc/articles/PMC3853740/ /pubmed/24284424 http://dx.doi.org/10.3390/md11114478 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ankisetty, Sridevi
Khan, Shabana I.
Avula, Bharathi
Gochfeld, Deborah
Khan, Ikhlas A.
Slattery, Marc
Chlorinated Didemnins from the Tunicate Trididemnum solidum
title Chlorinated Didemnins from the Tunicate Trididemnum solidum
title_full Chlorinated Didemnins from the Tunicate Trididemnum solidum
title_fullStr Chlorinated Didemnins from the Tunicate Trididemnum solidum
title_full_unstemmed Chlorinated Didemnins from the Tunicate Trididemnum solidum
title_short Chlorinated Didemnins from the Tunicate Trididemnum solidum
title_sort chlorinated didemnins from the tunicate trididemnum solidum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853740/
https://www.ncbi.nlm.nih.gov/pubmed/24284424
http://dx.doi.org/10.3390/md11114478
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