Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sens...

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Autores principales: Goren Zur, Lee, Bishara, Ashgan, Aknin, Maurice, Neumann, Drorit, Ben-Califa, Nathalie, Kashman, Yoel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853741/
https://www.ncbi.nlm.nih.gov/pubmed/24284425
http://dx.doi.org/10.3390/md11114487
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author Goren Zur, Lee
Bishara, Ashgan
Aknin, Maurice
Neumann, Drorit
Ben-Califa, Nathalie
Kashman, Yoel
author_facet Goren Zur, Lee
Bishara, Ashgan
Aknin, Maurice
Neumann, Drorit
Ben-Califa, Nathalie
Kashman, Yoel
author_sort Goren Zur, Lee
collection PubMed
description Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.
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spelling pubmed-38537412013-12-06 Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites Goren Zur, Lee Bishara, Ashgan Aknin, Maurice Neumann, Drorit Ben-Califa, Nathalie Kashman, Yoel Mar Drugs Article Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A. MDPI 2013-11-11 /pmc/articles/PMC3853741/ /pubmed/24284425 http://dx.doi.org/10.3390/md11114487 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Goren Zur, Lee
Bishara, Ashgan
Aknin, Maurice
Neumann, Drorit
Ben-Califa, Nathalie
Kashman, Yoel
Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites
title Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites
title_full Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites
title_fullStr Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites
title_full_unstemmed Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites
title_short Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites
title_sort derivatives of salarin a, salarin c and tulearin a—fascaplysinopsis sp. metabolites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853741/
https://www.ncbi.nlm.nih.gov/pubmed/24284425
http://dx.doi.org/10.3390/md11114487
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