Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration

BACKGROUND: Antagonists of N-type voltage-gated calcium channels (VGCC), Ca(v)2.2, can manage severe chronic pain with intrathecal use and may be effective systemically. A series of novel ω-conotoxins that selectively inhibit N-type VGCCs was isolated from Conus catus. In the present study, the pote...

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Detalles Bibliográficos
Autores principales: Sadeghi, Mahsa, Murali, Swetha S, Lewis, Richard J, Alewood, Paul F, Mohammadi, Sarasa, Christie, MacDonald J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853768/
https://www.ncbi.nlm.nih.gov/pubmed/24139484
http://dx.doi.org/10.1186/1744-8069-9-51

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