Cargando…

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease

Introduction: Unliganded iron both contributes to the pathology of Alzheimer's disease (AD) and also changes the morphology of erythrocytes (RBCs). We tested the hypothesis that these two facts might be linked, i.e., that the RBCs of AD individuals have a variant morphology, that might have dia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bester, Janette, Buys, Antoinette V., Lipinski, Boguslaw, Kell, Douglas B., Pretorius, Etheresia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853801/ https://www.ncbi.nlm.nih.gov/pubmed/24367334 http://dx.doi.org/10.3389/fnagi.2013.00088

Ejemplares similares

Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents
por: Pretorius, Etheresia, et al.
Publicado: (2014)

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics
por: Pretorius, Etheresia, et al.
Publicado: (2015)

The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia
por: Pretorius, Etheresia, et al.
Publicado: (2018)

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease
por: Pretorius, Etheresia, et al.
Publicado: (2016)

The Role of Iron-Induced Fibrin in the Pathogenesis of Alzheimer’s Disease and the Protective Role of Magnesium
por: Lipinski, Boguslaw, et al.
Publicado: (2013)

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)
por: Bester, Janette, et al.
Publicado: (2015)

Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity
por: Bester, Janette, et al.
Publicado: (2016)

Oxidation Inhibits Iron-Induced Blood Coagulation
por: Pretorius, Etheresia, et al.
Publicado: (2013)

Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation
por: Pretorius, Etheresia, et al.
Publicado: (2014)

Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer’s Type Dementia
por: Pretorius, Lesha, et al.
Publicado: (2018)

The dormant blood microbiome in chronic, inflammatory diseases
por: Potgieter, Marnie, et al.
Publicado: (2015)

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide
por: Pretorius, Etheresia, et al.
Publicado: (2016)

A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study
por: de Villiers, Sulette, et al.
Publicado: (2019)

Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19
por: Venter, Chantelle, et al.
Publicado: (2020)

Viscoelasticity as a measurement of clot structure in poorly controlled type 2 diabetes patients: towards a precision and personalized medicine approach
por: Pretorius, Etheresia, et al.
Publicado: (2016)

Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics
por: Nunes, J. Massimo, et al.
Publicado: (2020)

Changes in red blood cell membrane structure in type 2 diabetes: a scanning electron and atomic force microscopy study
por: Buys, Antoinette V, et al.
Publicado: (2013)

The effect of physiological levels of South African puff adder (Bitis arietans) snake venom on blood cells: an in vitro model
por: Strydom, Morné A., et al.
Publicado: (2016)

Eryptosis as a marker of Parkinson's disease
por: Pretorius, Etheresia, et al.
Publicado: (2014)

Iron-Induced Fibrin in Cardiovascular Disease
por: Lipinski, Boguslaw, et al.
Publicado: (2013)

The inflammatory effects of TNF-α and complement component 3 on coagulation
por: Page, Martin J., et al.
Publicado: (2018)

Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability
por: Pretorius, Etheresia, et al.
Publicado: (2016)

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases
por: Kell, Douglas B., et al.
Publicado: (2018)

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?
por: Kell, Douglas B., et al.
Publicado: (2018)

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications
por: Kell, Douglas B., et al.
Publicado: (2022)

Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology
por: Kell, Douglas, et al.
Publicado: (2015)

An estrogen analogue and promising anticancer agent refrains from inducing morphological damage and reactive oxygen species generation in erythrocytes, fibrin and platelets: a pilot study
por: Repsold, Lisa, et al.
Publicado: (2014)

Comparison of Platelet Ultrastructure and Elastic Properties in Thrombo-Embolic Ischemic Stroke and Smoking Using Atomic Force and Scanning Electron Microscopy
por: Du Plooy, Jeanette Noel, et al.
Publicado: (2013)

Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities
por: Pretorius, Etheresia, et al.
Publicado: (2017)

Is Porphyromonas gingivalis involved in Parkinson’s disease?
por: Olsen, Ingar, et al.
Publicado: (2020)

Parkinson’s Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens
por: Adams, Büin, et al.
Publicado: (2019)

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria
por: Kell, Douglas B., et al.
Publicado: (2020)

The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation
por: Page, Martin J., et al.
Publicado: (2022)

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
por: Kell, Douglas B., et al.
Publicado: (2022)

Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses
por: Nunes, Jean M., et al.
Publicado: (2023)

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris
por: Visser, Maria J. E., et al.
Publicado: (2019)

Pathophysiological Changes in Erythrocytes Contributing to Complications of Inflammation and Coagulation in COVID-19
por: Soma, Prashilla, et al.
Publicado: (2022)

Platelet hyperactivity and fibrin clot structure in transient ischemic attack individuals in the presence of metabolic syndrome: a microscopy and thromboelastography(®) study
por: van Rooy, Mia-Jeanne, et al.
Publicado: (2015)

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes
por: Grobler, Corlia, et al.
Publicado: (2020)

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease
por: Pretorius, Etheresia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hcpsbjjbcvmclfqej995u4sb5s