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Transformation of Stimulus Correlations by the Retina

Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simu...

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Detalles Bibliográficos
Autores principales: Simmons, Kristina D., Prentice, Jason S., Tkačik, Gašper, Homann, Jan, Yee, Heather K., Palmer, Stephanie E., Nelson, Philip C., Balasubramanian, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854086/
https://www.ncbi.nlm.nih.gov/pubmed/24339756
http://dx.doi.org/10.1371/journal.pcbi.1003344
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author Simmons, Kristina D.
Prentice, Jason S.
Tkačik, Gašper
Homann, Jan
Yee, Heather K.
Palmer, Stephanie E.
Nelson, Philip C.
Balasubramanian, Vijay
author_facet Simmons, Kristina D.
Prentice, Jason S.
Tkačik, Gašper
Homann, Jan
Yee, Heather K.
Palmer, Stephanie E.
Nelson, Philip C.
Balasubramanian, Vijay
author_sort Simmons, Kristina D.
collection PubMed
description Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simultaneous responses from populations of retinal ganglion cells presented with natural and artificial stimuli that varied greatly in correlation structure; these stimuli and recordings are publicly available online. Responding to spatio-temporally structured stimuli such as natural movies, pairs of ganglion cells were modestly more correlated than in response to white noise checkerboards, but they were much less correlated than predicted by a non-adapting functional model of retinal response. Meanwhile, responding to stimuli with purely spatial correlations, pairs of ganglion cells showed increased correlations consistent with a static, non-adapting receptive field and nonlinearity. We found that in response to spatio-temporally correlated stimuli, ganglion cells had faster temporal kernels and tended to have stronger surrounds. These properties of individual cells, along with gain changes that opposed changes in effective contrast at the ganglion cell input, largely explained the pattern of pairwise correlations across stimuli where receptive field measurements were possible.
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spelling pubmed-38540862013-12-11 Transformation of Stimulus Correlations by the Retina Simmons, Kristina D. Prentice, Jason S. Tkačik, Gašper Homann, Jan Yee, Heather K. Palmer, Stephanie E. Nelson, Philip C. Balasubramanian, Vijay PLoS Comput Biol Research Article Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simultaneous responses from populations of retinal ganglion cells presented with natural and artificial stimuli that varied greatly in correlation structure; these stimuli and recordings are publicly available online. Responding to spatio-temporally structured stimuli such as natural movies, pairs of ganglion cells were modestly more correlated than in response to white noise checkerboards, but they were much less correlated than predicted by a non-adapting functional model of retinal response. Meanwhile, responding to stimuli with purely spatial correlations, pairs of ganglion cells showed increased correlations consistent with a static, non-adapting receptive field and nonlinearity. We found that in response to spatio-temporally correlated stimuli, ganglion cells had faster temporal kernels and tended to have stronger surrounds. These properties of individual cells, along with gain changes that opposed changes in effective contrast at the ganglion cell input, largely explained the pattern of pairwise correlations across stimuli where receptive field measurements were possible. Public Library of Science 2013-12-05 /pmc/articles/PMC3854086/ /pubmed/24339756 http://dx.doi.org/10.1371/journal.pcbi.1003344 Text en © 2013 Simmons et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Simmons, Kristina D.
Prentice, Jason S.
Tkačik, Gašper
Homann, Jan
Yee, Heather K.
Palmer, Stephanie E.
Nelson, Philip C.
Balasubramanian, Vijay
Transformation of Stimulus Correlations by the Retina
title Transformation of Stimulus Correlations by the Retina
title_full Transformation of Stimulus Correlations by the Retina
title_fullStr Transformation of Stimulus Correlations by the Retina
title_full_unstemmed Transformation of Stimulus Correlations by the Retina
title_short Transformation of Stimulus Correlations by the Retina
title_sort transformation of stimulus correlations by the retina
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854086/
https://www.ncbi.nlm.nih.gov/pubmed/24339756
http://dx.doi.org/10.1371/journal.pcbi.1003344
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