A fingerprint pair analysis of hERG inhibition data

BACKGROUND: Drugs that bind to the human Ether-a-go-go Related Gene (hERG) potassium channel and block its ion conduction can lead to Torsade de Pointes (TdP), a fatal ventricular arrhythmia. Thus, compounds are screened for hERG inhibition in the drug development process; those found to be active f...

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Detalles Bibliográficos
Autores principales: Springer, Clayton, Sokolnicki, Katherine L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854090/
https://www.ncbi.nlm.nih.gov/pubmed/24144230
http://dx.doi.org/10.1186/1752-153X-7-167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854090/
https://www.ncbi.nlm.nih.gov/pubmed/24144230
http://dx.doi.org/10.1186/1752-153X-7-167

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