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The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients
PURPOSE: This study was conducted to analyze the feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: From July 2008 to January 2012, 52 patients with stage N1 NPC were analyzed. All patients were treated with...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854105/ https://www.ncbi.nlm.nih.gov/pubmed/24094078 http://dx.doi.org/10.1186/1748-717X-8-230 |
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author | Hu, Weixu Zhu, Guopei Guan, Xiyin Wang, Xiaoshen Hu, Chaosu |
author_facet | Hu, Weixu Zhu, Guopei Guan, Xiyin Wang, Xiaoshen Hu, Chaosu |
author_sort | Hu, Weixu |
collection | PubMed |
description | PURPOSE: This study was conducted to analyze the feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: From July 2008 to January 2012, 52 patients with stage N1 NPC were analyzed. All patients were treated with intensity-modulated radiation therapy (IMRT) and received bilateral upper neck irradiation to levels II, III and VA and ipsilateral lower neck irradiation to levels IV and VB. The contralateral lower neck irradiation was omitted. RESULTS: The median follow-up was 29 months (range, 12–52 months). The 3-year overall survival (OS) rate, progress-free survival (PFS), local failure-free (LFS), nodal recurrence-free survival (NFS) and distant metastasis-free survival (DMFS) rates were 92.2%, 94.1%, 94.3%, 98% and 94.1%, respectively. Only one patient developed a neck recurrence in the irradiation field, while no patients experienced out-of-field nodal recurrence. Univariate analysis suggested that T classification was the only significant prognostic factor for overall survival, and age was significantly associated with PFS. Multivariate analyses indicated that age was also a predictor for overall survival. The elective neck irradiation procedure was not a significant predictor for all of the treatment results. CONCLUSION: Selective irradiation to bilateral levels of II, III and VA and unilateral levels of IV and VB, omitted the contralateral lower neck in a proportion of patients with N1 stage NPC was safe and practicable. |
format | Online Article Text |
id | pubmed-3854105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38541052013-12-07 The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients Hu, Weixu Zhu, Guopei Guan, Xiyin Wang, Xiaoshen Hu, Chaosu Radiat Oncol Research PURPOSE: This study was conducted to analyze the feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: From July 2008 to January 2012, 52 patients with stage N1 NPC were analyzed. All patients were treated with intensity-modulated radiation therapy (IMRT) and received bilateral upper neck irradiation to levels II, III and VA and ipsilateral lower neck irradiation to levels IV and VB. The contralateral lower neck irradiation was omitted. RESULTS: The median follow-up was 29 months (range, 12–52 months). The 3-year overall survival (OS) rate, progress-free survival (PFS), local failure-free (LFS), nodal recurrence-free survival (NFS) and distant metastasis-free survival (DMFS) rates were 92.2%, 94.1%, 94.3%, 98% and 94.1%, respectively. Only one patient developed a neck recurrence in the irradiation field, while no patients experienced out-of-field nodal recurrence. Univariate analysis suggested that T classification was the only significant prognostic factor for overall survival, and age was significantly associated with PFS. Multivariate analyses indicated that age was also a predictor for overall survival. The elective neck irradiation procedure was not a significant predictor for all of the treatment results. CONCLUSION: Selective irradiation to bilateral levels of II, III and VA and unilateral levels of IV and VB, omitted the contralateral lower neck in a proportion of patients with N1 stage NPC was safe and practicable. BioMed Central 2013-10-04 /pmc/articles/PMC3854105/ /pubmed/24094078 http://dx.doi.org/10.1186/1748-717X-8-230 Text en Copyright © 2013 Hu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Hu, Weixu Zhu, Guopei Guan, Xiyin Wang, Xiaoshen Hu, Chaosu The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients |
title | The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients |
title_full | The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients |
title_fullStr | The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients |
title_full_unstemmed | The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients |
title_short | The feasibility of omitting irradiation to the contralateral lower neck in stage N1 nasopharyngeal carcinoma patients |
title_sort | feasibility of omitting irradiation to the contralateral lower neck in stage n1 nasopharyngeal carcinoma patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854105/ https://www.ncbi.nlm.nih.gov/pubmed/24094078 http://dx.doi.org/10.1186/1748-717X-8-230 |
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