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A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumor growth

Doxorubicin (DOX) was conjugated to a single-chain variable fragment (scFv) against human midkine (MK), and the conjugate (scFv-DOX) was used to target the chemotherapeutic agent to a mouse solid tumor model in which the tumor cells expressed high levels of human MK. The His-tagged recombinant scFv...

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Detalles Bibliográficos
Autores principales:	Zhao, Shuli, Zhao, Guangfeng, Xie, Hao, Huang, Yahong, Hou, Yayi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Medicina Tropical 2012
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854202/ https://www.ncbi.nlm.nih.gov/pubmed/22267001 http://dx.doi.org/10.1590/S0100-879X2012007500009

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