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Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the P...

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Detalles Bibliográficos
Autores principales: Murat, C.B., Braga, P.B.S., Fortes, M.A.H.Z., Bronstein, M.D., Corrêa-Giannella, M.L.C., Giorgi, R.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854320/
https://www.ncbi.nlm.nih.gov/pubmed/22782554
http://dx.doi.org/10.1590/S0100-879X2012007500115