Cargando…

Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice

The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786) were prepared from 2-thienylidene 3,4-methylenedioxybenzoylhydrazine (LASSBio-294). The ability of LASSBio-785 and LASSBio-786 to decrease cen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Silva, G.A.P., Kummerle, A.E., Antunes, F., Fraga, C.A.M., Barreiro, E.J., Zapata-Sudo, G., Sudo, R.T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Divulgação Científica 2013
Materias:	Biomedical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854378/ https://www.ncbi.nlm.nih.gov/pubmed/23558854 http://dx.doi.org/10.1590/1414-431X20122085

Ejemplares similares

LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice
por: Silva, Juliane Cabral, et al.
Publicado: (2018)

Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514
por: Lima, Lidia Moreira, et al.
Publicado: (2021)

Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A(2A) receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats
por: Alencar, Allan K., et al.
Publicado: (2018)

Therapeutic effects of LASSBio-596 in an elastase-induced mouse model of emphysema
por: Padilha, Gisele A., et al.
Publicado: (2015)

Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H(2)LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H(2)LASSBio-1064) and Their Zinc(II) Complexes
por: Júnior, Walfrido Bispo, et al.
Publicado: (2011)

Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs
por: Barbosa, Gisele, et al.
Publicado: (2022)

LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A(2A) Receptor
por: Carvalho, Vinicius F., et al.
Publicado: (2017)

Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity
por: de Queiroz, Aline Cavalcanti, et al.
Publicado: (2022)

Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent
por: Guimarães, Celina de Jesus, et al.
Publicado: (2023)

LASSBio-1135: A Dual TRPV1 Antagonist and Anti-TNF-Alpha Compound Orally Effective in Models of Inflammatory and Neuropathic Pain
por: Lima, Cleverton K. F., et al.
Publicado: (2014)

Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D(2) Receptor
por: Silva, Rafaela R., et al.
Publicado: (2019)

In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis
por: Silva, Dahara Keyse Carvalho, et al.
Publicado: (2020)

Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives
por: Lopes, Alexandra Basilio, et al.
Publicado: (2013)

Novel Orally Active Analgesic and Anti-Inflammatory Cyclohexyl-N-Acylhydrazone Derivatives
por: da Silva, Tiago Fernandes, et al.
Publicado: (2015)

New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis
por: Costa, Gizele Cabral, et al.
Publicado: (2020)

Fungal Planet description sheets: 785–867
por: Crous, P.W., et al.
Publicado: (2018)

Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A
por: Furtado, F.M., et al.
Publicado: (2017)

Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives
por: Carvalho, Samir Aquino, et al.
Publicado: (2014)

Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines
por: Park, S.H., et al.
Publicado: (2014)

Association between anaerobic components of the maximal accumulated oxygen deficit and 30-second Wingate test
por: Bertuzzi, R., et al.
Publicado: (2015)

Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease
por: de Freitas Silva, Matheus, et al.
Publicado: (2020)

N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain
por: Horst, A., et al.
Publicado: (2017)

Molecular Alterations Prompted by SARS-CoV-2 Infection: Induction of Hyaluronan, Glycosaminoglycan and Mucopolysaccharide Metabolism
por: Andonegui-Elguera, Sergio, et al.
Publicado: (2020)

Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study
por: Baby, Krishnaprasad, et al.
Publicado: (2021)

Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019
por: Wang, Ting, et al.
Publicado: (2021)

Predictive Value of CAR for In-Hospital Mortality in Patients with COVID-19 Pneumonia: A Retrospective Cohort Study
por: Güney, Başak Çakır, et al.
Publicado: (2021)

Methylmercury inhibits prolactin release in a cell line of pituitary origin
por: Maués, L.A.L., et al.
Publicado: (2015)

Trypan blue exclusion assay by flow cytometry
por: Avelar-Freitas, B.A., et al.
Publicado: (2014)

Interaction between affordance and handedness recognition: a chronometric study
por: Lameira, A.P., et al.
Publicado: (2015)

Increased immunoglobulin production in silver catfish (Rhamdia quelen) exposed to agrichemicals
por: Kreutz, L.C., et al.
Publicado: (2014)

Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative
por: Bastos, Isadora T. S., et al.
Publicado: (2018)

Acylhydrazones and Their Biological Activity: A Review
por: Socea, Laura-Ileana, et al.
Publicado: (2022)

Effect of scanner acoustic background noise on strict resting-state fMRI
por: Rondinoni, C., et al.
Publicado: (2013)

Study of the reaction $K^{+}$ p -> K $\pi$ N at 735 and 785 MeV/c
por: Filippas-Tassos, A, et al.
Publicado: (1967)

Oxygen uptake, respiratory exchange ratio, or total distance: a comparison of methods to equalize exercise volume in Wistar rats
por: Paes, L.S., et al.
Publicado: (2016)

Swimming training prevents coronary endothelial dysfunction in ovariectomized spontaneously hypertensive rats
por: Claudio, E.R.G., et al.
Publicado: (2017)

Time-course effects of aerobic exercise training on cardiovascular and renal parameters in 2K1C renovascular hypertensive rats
por: Maia, R.C.A., et al.
Publicado: (2015)

Epilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in rats
por: Tavares, J.G.P., et al.
Publicado: (2015)

Novel Regioisomeric Analogues of Naphthyl-N-Acylhydrazone Derivatives and Their Anti-Inflammatory Effects
por: da Costa Salomé, Dayana, et al.
Publicado: (2022)

Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats
por: Issy, A.C., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_nnrtl0gir18osbjqu7qe5n3e1o