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H(1) but not H(2) histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
This study investigated the role of H(1) and H(2) receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injecti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação
Científica
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854398/ https://www.ncbi.nlm.nih.gov/pubmed/23598647 http://dx.doi.org/10.1590/1414-431X20132770 |
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author | Serafim, K.R. Kishi, M.S. Canto-de-Souza, A. Mattioli, R. |
author_facet | Serafim, K.R. Kishi, M.S. Canto-de-Souza, A. Mattioli, R. |
author_sort | Serafim, K.R. |
collection | PubMed |
description | This study investigated the role of H(1) and H(2) receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20 mg/kg zolantidine (ZOL, an H(2) receptor antagonist), or 8.0 or 16 mg/kg chlorpheniramine (CPA, an H(1) receptor antagonist). After 40 min, they were subjected to the EPM test. In T2 (24 h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8 mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16 mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8 mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H(1) receptor, but not H(2), is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing. |
format | Online Article Text |
id | pubmed-3854398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Associação Brasileira de Divulgação
Científica |
record_format | MEDLINE/PubMed |
spelling | pubmed-38543982013-12-16 H(1) but not H(2) histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing Serafim, K.R. Kishi, M.S. Canto-de-Souza, A. Mattioli, R. Braz J Med Biol Res Biomedical Sciences This study investigated the role of H(1) and H(2) receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20 mg/kg zolantidine (ZOL, an H(2) receptor antagonist), or 8.0 or 16 mg/kg chlorpheniramine (CPA, an H(1) receptor antagonist). After 40 min, they were subjected to the EPM test. In T2 (24 h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8 mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16 mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8 mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H(1) receptor, but not H(2), is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing. Associação Brasileira de Divulgação Científica 2013-04-19 /pmc/articles/PMC3854398/ /pubmed/23598647 http://dx.doi.org/10.1590/1414-431X20132770 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Biomedical Sciences Serafim, K.R. Kishi, M.S. Canto-de-Souza, A. Mattioli, R. H(1) but not H(2) histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing |
title | H(1) but not H(2) histamine
antagonist receptors mediate anxiety-related behaviors and emotional memory
deficit in mice subjected to elevated plus-maze testing |
title_full | H(1) but not H(2) histamine
antagonist receptors mediate anxiety-related behaviors and emotional memory
deficit in mice subjected to elevated plus-maze testing |
title_fullStr | H(1) but not H(2) histamine
antagonist receptors mediate anxiety-related behaviors and emotional memory
deficit in mice subjected to elevated plus-maze testing |
title_full_unstemmed | H(1) but not H(2) histamine
antagonist receptors mediate anxiety-related behaviors and emotional memory
deficit in mice subjected to elevated plus-maze testing |
title_short | H(1) but not H(2) histamine
antagonist receptors mediate anxiety-related behaviors and emotional memory
deficit in mice subjected to elevated plus-maze testing |
title_sort | h(1) but not h(2) histamine
antagonist receptors mediate anxiety-related behaviors and emotional memory
deficit in mice subjected to elevated plus-maze testing |
topic | Biomedical Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854398/ https://www.ncbi.nlm.nih.gov/pubmed/23598647 http://dx.doi.org/10.1590/1414-431X20132770 |
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