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Under the right conditions: protecting podocytes from diabetes-induced damage
Hyperglycemia-induced damage to the glomerular podocyte is thought to be a critical early event in diabetic nephropathy. Interventions that prevent podocyte damage or loss have been shown to have potential for the treatment of diabetic nephropathy. New data show that conditioned medium from adipocyt...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854696/ https://www.ncbi.nlm.nih.gov/pubmed/24083666 http://dx.doi.org/10.1186/scrt330 |
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author | Ali, Imran HA Brazil, Derek P |
author_facet | Ali, Imran HA Brazil, Derek P |
author_sort | Ali, Imran HA |
collection | PubMed |
description | Hyperglycemia-induced damage to the glomerular podocyte is thought to be a critical early event in diabetic nephropathy. Interventions that prevent podocyte damage or loss have been shown to have potential for the treatment of diabetic nephropathy. New data show that conditioned medium from adipocyte-derived mesenchymal stem cells has the potential to protect podocytes from high-glucose-induced damage. Furthermore, epidermal growth factor may be the critical ingredient mediating this effect. These data suggest that components of the conditioned medium of mesenchymal stem cells, in addition to the cells themselves, may have potential for the treatment of diseases such as diabetic nephropathy. |
format | Online Article Text |
id | pubmed-3854696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38546962014-10-03 Under the right conditions: protecting podocytes from diabetes-induced damage Ali, Imran HA Brazil, Derek P Stem Cell Res Ther Commentary Hyperglycemia-induced damage to the glomerular podocyte is thought to be a critical early event in diabetic nephropathy. Interventions that prevent podocyte damage or loss have been shown to have potential for the treatment of diabetic nephropathy. New data show that conditioned medium from adipocyte-derived mesenchymal stem cells has the potential to protect podocytes from high-glucose-induced damage. Furthermore, epidermal growth factor may be the critical ingredient mediating this effect. These data suggest that components of the conditioned medium of mesenchymal stem cells, in addition to the cells themselves, may have potential for the treatment of diseases such as diabetic nephropathy. BioMed Central 2013-10-02 /pmc/articles/PMC3854696/ /pubmed/24083666 http://dx.doi.org/10.1186/scrt330 Text en Copyright © 2013 BioMed Central Ltd. |
spellingShingle | Commentary Ali, Imran HA Brazil, Derek P Under the right conditions: protecting podocytes from diabetes-induced damage |
title | Under the right conditions: protecting podocytes from diabetes-induced damage |
title_full | Under the right conditions: protecting podocytes from diabetes-induced damage |
title_fullStr | Under the right conditions: protecting podocytes from diabetes-induced damage |
title_full_unstemmed | Under the right conditions: protecting podocytes from diabetes-induced damage |
title_short | Under the right conditions: protecting podocytes from diabetes-induced damage |
title_sort | under the right conditions: protecting podocytes from diabetes-induced damage |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854696/ https://www.ncbi.nlm.nih.gov/pubmed/24083666 http://dx.doi.org/10.1186/scrt330 |
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