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Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei
Dynamic models of metabolism can be useful in identifying potential drug targets, especially in unicellular organisms. A model of glycolysis in the causative agent of human African trypanosomiasis, Trypanosoma brucei, has already shown the utility of this approach. Here we add the pentose phosphate...
Autores principales: | Kerkhoven, Eduard J., Achcar, Fiona, Alibu, Vincent P., Burchmore, Richard J., Gilbert, Ian H., Trybiło, Maciej, Driessen, Nicole N., Gilbert, David, Breitling, Rainer, Bakker, Barbara M., Barrett, Michael P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854711/ https://www.ncbi.nlm.nih.gov/pubmed/24339766 http://dx.doi.org/10.1371/journal.pcbi.1003371 |
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