BMPR1B Up-Regulation via a miRNA Binding Site Variation Defines Endometriosis Susceptibility and CA125 Levels

BACKGROUND: Bone morphogenetic protein receptor I B (BMPR1B) is a transmembrane receptor mediating TGF-β signal transduction. Recent studies indicate a tumor suppressor role for BMPR1B in ovarian cancer. Polymorphism at BMPR1B 3′UTR within the miR-125b binding site alters its binding affinity toward...

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Detalles Bibliográficos
Autores principales: Chang, Cherry Yin-Yi, Chen, Yi, Lai, Ming-Tsung, Chang, Hui-Wen, Cheng, Jack, Chan, Carmen, Chen, Chih-Mei, Lee, Shan-Chih, Lin, Ying-Ju, Wan, Lei, Tsai, Pei-Wen, Yang, Su-Han, Chung, Ching, Sheu, Jim Jinn-Chyuan, Tsai, Fuu-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855056/
https://www.ncbi.nlm.nih.gov/pubmed/24339876
http://dx.doi.org/10.1371/journal.pone.0080630

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