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S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis
BACKGROUND: Currently, there are no valid and reliable biomarkers to identify delirious patients predisposed to longer delirium duration. We investigated the hypothesis that elevated S100 calcium binding protein B (S100β) levels will be associated with longer delirium duration in critically ill pati...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855164/ https://www.ncbi.nlm.nih.gov/pubmed/24324346 http://dx.doi.org/10.2147/IJGM.S51004 |
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author | Khan, Babar A Farber, Mark O Campbell, Noll Perkins, Anthony Prasad, Nagendra K Hui, Siu L Miller, Douglas K Calvo-Ayala, Enrique Buckley, John D Ionescu, Ruxandra Shekhar, Anantha Ely, E Wesley Boustani, Malaz A |
author_facet | Khan, Babar A Farber, Mark O Campbell, Noll Perkins, Anthony Prasad, Nagendra K Hui, Siu L Miller, Douglas K Calvo-Ayala, Enrique Buckley, John D Ionescu, Ruxandra Shekhar, Anantha Ely, E Wesley Boustani, Malaz A |
author_sort | Khan, Babar A |
collection | PubMed |
description | BACKGROUND: Currently, there are no valid and reliable biomarkers to identify delirious patients predisposed to longer delirium duration. We investigated the hypothesis that elevated S100 calcium binding protein B (S100β) levels will be associated with longer delirium duration in critically ill patients. METHODS: A prospective observational cohort study was performed in the medical, surgical, and progressive intensive care units (ICUs) of a tertiary care, university affiliated, and urban hospital. Sixty-three delirious patients were selected for the analysis, with two samples of S100β collected on days 1 and 8 of enrollment. The main outcome measure was delirium duration. Using the cutoff of <0.1 ng/mL and ≥0.1 ng/mL as normal and abnormal levels of S100β, respectively, on day 1 and day 8, four exposure groups were created: Group A, normal S100β levels on day 1 and day 8; Group B, normal S100β level on day 1 and abnormal S100β level on day 8; Group C, abnormal S100β level on day 1 and normal on day 8; and Group D, abnormal S100β levels on both day 1 and day 8. RESULTS: Patients with abnormal levels of S100β showed a trend towards higher delirium duration (P=0.076); Group B (standard deviation) (7.0 [3.2] days), Group C (5.5 [6.3] days), and Group D (5.3 [6.0] days), compared to patients in Group A (3.5 [5.4] days). CONCLUSION: This preliminary investigation identified a potentially novel role for S100β as a biomarker for delirium duration in critically ill patients. This finding may have important implications for refining future delirium management strategies in ICU patients. |
format | Online Article Text |
id | pubmed-3855164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38551642013-12-09 S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis Khan, Babar A Farber, Mark O Campbell, Noll Perkins, Anthony Prasad, Nagendra K Hui, Siu L Miller, Douglas K Calvo-Ayala, Enrique Buckley, John D Ionescu, Ruxandra Shekhar, Anantha Ely, E Wesley Boustani, Malaz A Int J Gen Med Original Research BACKGROUND: Currently, there are no valid and reliable biomarkers to identify delirious patients predisposed to longer delirium duration. We investigated the hypothesis that elevated S100 calcium binding protein B (S100β) levels will be associated with longer delirium duration in critically ill patients. METHODS: A prospective observational cohort study was performed in the medical, surgical, and progressive intensive care units (ICUs) of a tertiary care, university affiliated, and urban hospital. Sixty-three delirious patients were selected for the analysis, with two samples of S100β collected on days 1 and 8 of enrollment. The main outcome measure was delirium duration. Using the cutoff of <0.1 ng/mL and ≥0.1 ng/mL as normal and abnormal levels of S100β, respectively, on day 1 and day 8, four exposure groups were created: Group A, normal S100β levels on day 1 and day 8; Group B, normal S100β level on day 1 and abnormal S100β level on day 8; Group C, abnormal S100β level on day 1 and normal on day 8; and Group D, abnormal S100β levels on both day 1 and day 8. RESULTS: Patients with abnormal levels of S100β showed a trend towards higher delirium duration (P=0.076); Group B (standard deviation) (7.0 [3.2] days), Group C (5.5 [6.3] days), and Group D (5.3 [6.0] days), compared to patients in Group A (3.5 [5.4] days). CONCLUSION: This preliminary investigation identified a potentially novel role for S100β as a biomarker for delirium duration in critically ill patients. This finding may have important implications for refining future delirium management strategies in ICU patients. Dove Medical Press 2013-12-02 /pmc/articles/PMC3855164/ /pubmed/24324346 http://dx.doi.org/10.2147/IJGM.S51004 Text en © 2013 Khan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Khan, Babar A Farber, Mark O Campbell, Noll Perkins, Anthony Prasad, Nagendra K Hui, Siu L Miller, Douglas K Calvo-Ayala, Enrique Buckley, John D Ionescu, Ruxandra Shekhar, Anantha Ely, E Wesley Boustani, Malaz A S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis |
title | S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis |
title_full | S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis |
title_fullStr | S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis |
title_full_unstemmed | S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis |
title_short | S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis |
title_sort | s100 calcium binding protein b as a biomarker of delirium duration in the intensive care unit – an exploratory analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855164/ https://www.ncbi.nlm.nih.gov/pubmed/24324346 http://dx.doi.org/10.2147/IJGM.S51004 |
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