Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone

Prostate cancer (PC) bone metastases show weak responses to conventional therapies. Bone matrix is rich in growth factors, with insulin-like growth factor-1 (IGF-1) being one of the most abundant. IGF-1 acts as a survival factor for tumor cells and we speculate that bone-derived IGF-1 counteracts ef...

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Detalles Bibliográficos
Autores principales: Nordstrand, Annika, Lundholm, Marie, Larsson, Andreas, Lerner, Ulf H., Widmark, Anders, Wikström, Pernilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855371/
https://www.ncbi.nlm.nih.gov/pubmed/23335094
http://dx.doi.org/10.1007/s12307-013-0129-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855371/
https://www.ncbi.nlm.nih.gov/pubmed/23335094
http://dx.doi.org/10.1007/s12307-013-0129-z

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