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Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone

Prostate cancer (PC) bone metastases show weak responses to conventional therapies. Bone matrix is rich in growth factors, with insulin-like growth factor-1 (IGF-1) being one of the most abundant. IGF-1 acts as a survival factor for tumor cells and we speculate that bone-derived IGF-1 counteracts ef...

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Detalles Bibliográficos
Autores principales:	Nordstrand, Annika, Lundholm, Marie, Larsson, Andreas, Lerner, Ulf H., Widmark, Anders, Wikström, Pernilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2013
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855371/ https://www.ncbi.nlm.nih.gov/pubmed/23335094 http://dx.doi.org/10.1007/s12307-013-0129-z

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