AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes

Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of AMPK results in the mobilization of nutrient uptake and catabolism for mitochondrial ATP generation to restor...

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Detalles Bibliográficos
Autores principales: Jenkins, Yonchu, Sun, Tian-Qiang, Markovtsov, Vadim, Foretz, Marc, Li, Wei, Nguyen, Henry, Li, Yingwu, Pan, Alison, Uy, Gerald, Gross, Lisa, Baltgalvis, Kristen, Yung, Stephanie L., Gururaja, Tarikere, Kinoshita, Taisei, Owyang, Alexander, Smith, Ira J., McCaughey, Kelly, White, Kathy, Godinez, Guillermo, Alcantara, Raniel, Choy, Carmen, Ren, Hong, Basile, Rachel, Sweeny, David J., Xu, Xiang, Issakani, Sarkiz D., Carroll, David C., Goff, Dane A., Shaw, Simon J., Singh, Rajinder, Boros, Laszlo G., Laplante, Marc-André, Marcotte, Bruno, Kohen, Rita, Viollet, Benoit, Marette, André, Payan, Donald G., Kinsella, Todd M., Hitoshi, Yasumichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855387/
https://www.ncbi.nlm.nih.gov/pubmed/24339975
http://dx.doi.org/10.1371/journal.pone.0081870

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