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Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009

BACKGROUND: Influenza pandemics have significant operational impact on deployed military personnel working in areas throughout the world. The US Department of Defense global influenza-like illness (ILI) surveillance network serves an important role in establishing baseline trends and can be leverage...

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Autores principales: Cosby, Michael T., Pimentel, Guillermo, Nevin, Remington L., Fouad Ahmed, Salwa, Klena, John D., Amir, Ehab, Younan, Mary, Browning, Robert, Sebeny, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855413/
https://www.ncbi.nlm.nih.gov/pubmed/24339995
http://dx.doi.org/10.1371/journal.pone.0082089
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author Cosby, Michael T.
Pimentel, Guillermo
Nevin, Remington L.
Fouad Ahmed, Salwa
Klena, John D.
Amir, Ehab
Younan, Mary
Browning, Robert
Sebeny, Peter J.
author_facet Cosby, Michael T.
Pimentel, Guillermo
Nevin, Remington L.
Fouad Ahmed, Salwa
Klena, John D.
Amir, Ehab
Younan, Mary
Browning, Robert
Sebeny, Peter J.
author_sort Cosby, Michael T.
collection PubMed
description BACKGROUND: Influenza pandemics have significant operational impact on deployed military personnel working in areas throughout the world. The US Department of Defense global influenza-like illness (ILI) surveillance network serves an important role in establishing baseline trends and can be leveraged to respond to outbreaks of respiratory illness. OBJECTIVE: We identified and characterized an operationally unique outbreak of H3N2 influenza at Camp Lemonnier, Djibouti occurring simultaneously with the H1N1 pandemic of 2009 [A(H1N1)pdm09]. METHODS: Enhanced surveillance for ILI was conducted at Camp Lemonnier in response to local reports of a possible outbreak during the A(H1N1)pdm09 pandemic. Samples were collected from consenting patients presenting with ILI (utilizing a modified case definition) and who completed a case report form. Samples were cultured and analyzed using standard real-time reverse transcriptase PCR (rt-RT-PCR) methodology and sequenced genetic material was phylogenetically compared to other published strains. RESULTS: rt-RT-PCR and DNA sequencing revealed that 25 (78%) of the 32 clinical samples collected were seasonal H3N2 and only 2 (6%) were A(H1N1)pdm09 influenza. The highest incidence of H3N2 occurred during the month of May and 80% of these were active duty military personnel. Phylogenetic analysis revealed that sequenced H3N2 strains were genetically similar to 2009 strains from the United States of America, Australia, and South east Asia. CONCLUSIONS: This outbreak highlights challenges in the investigation of influenza among deployed military populations and corroborates the public health importance of maintaining surveillance systems for ILI that can be enhanced locally when needed.
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spelling pubmed-38554132013-12-11 Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009 Cosby, Michael T. Pimentel, Guillermo Nevin, Remington L. Fouad Ahmed, Salwa Klena, John D. Amir, Ehab Younan, Mary Browning, Robert Sebeny, Peter J. PLoS One Research Article BACKGROUND: Influenza pandemics have significant operational impact on deployed military personnel working in areas throughout the world. The US Department of Defense global influenza-like illness (ILI) surveillance network serves an important role in establishing baseline trends and can be leveraged to respond to outbreaks of respiratory illness. OBJECTIVE: We identified and characterized an operationally unique outbreak of H3N2 influenza at Camp Lemonnier, Djibouti occurring simultaneously with the H1N1 pandemic of 2009 [A(H1N1)pdm09]. METHODS: Enhanced surveillance for ILI was conducted at Camp Lemonnier in response to local reports of a possible outbreak during the A(H1N1)pdm09 pandemic. Samples were collected from consenting patients presenting with ILI (utilizing a modified case definition) and who completed a case report form. Samples were cultured and analyzed using standard real-time reverse transcriptase PCR (rt-RT-PCR) methodology and sequenced genetic material was phylogenetically compared to other published strains. RESULTS: rt-RT-PCR and DNA sequencing revealed that 25 (78%) of the 32 clinical samples collected were seasonal H3N2 and only 2 (6%) were A(H1N1)pdm09 influenza. The highest incidence of H3N2 occurred during the month of May and 80% of these were active duty military personnel. Phylogenetic analysis revealed that sequenced H3N2 strains were genetically similar to 2009 strains from the United States of America, Australia, and South east Asia. CONCLUSIONS: This outbreak highlights challenges in the investigation of influenza among deployed military populations and corroborates the public health importance of maintaining surveillance systems for ILI that can be enhanced locally when needed. Public Library of Science 2013-12-05 /pmc/articles/PMC3855413/ /pubmed/24339995 http://dx.doi.org/10.1371/journal.pone.0082089 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Cosby, Michael T.
Pimentel, Guillermo
Nevin, Remington L.
Fouad Ahmed, Salwa
Klena, John D.
Amir, Ehab
Younan, Mary
Browning, Robert
Sebeny, Peter J.
Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009
title Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009
title_full Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009
title_fullStr Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009
title_full_unstemmed Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009
title_short Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 Pandemic of 2009
title_sort outbreak of h3n2 influenza at a us military base in djibouti during the h1n1 pandemic of 2009
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855413/
https://www.ncbi.nlm.nih.gov/pubmed/24339995
http://dx.doi.org/10.1371/journal.pone.0082089
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