Cargando…

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

AIMS/HYPOTHESIS: Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected in patients with long-standing type 1 diabetes. It is not k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oram, Richard A., Jones, Angus G., Besser, Rachel E. J., Knight, Bridget A., Shields, Beverley M., Brown, Richard J., Hattersley, Andrew T., McDonald, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855529/ https://www.ncbi.nlm.nih.gov/pubmed/24121625 http://dx.doi.org/10.1007/s00125-013-3067-x

Ejemplares similares

Erratum to: The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells
por: Oram, Richard A., et al.
Publicado: (2013)

Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study
por: Oram, Richard A, et al.
Publicado: (2013)

Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin
por: Jones, Angus G, et al.
Publicado: (2012)

Urinary C-Peptide Creatinine Ratio Is a Practical Outpatient Tool for Identifying Hepatocyte Nuclear Factor 1-α/Hepatocyte Nuclear Factor 4-α Maturity-Onset Diabetes of the Young From Long-Duration Type 1 Diabetes
por: Besser, Rachel E.J., et al.
Publicado: (2011)

Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes
por: Besser, Rachel E.J., et al.
Publicado: (2011)

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18–50 years
por: Lynam, Anita, et al.
Publicado: (2019)

Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes
por: Thomas, Nicholas J., et al.
Publicado: (2019)

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis
por: Leete, Pia, et al.
Publicado: (2020)

Urinary C‐peptide creatinine ratio detects absolute insulin deficiency in Type 2 diabetes
por: Hope, S. V., et al.
Publicado: (2013)

Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis
por: Hope, Suzy V, et al.
Publicado: (2016)

Identifying clinical criteria to predict Type 1 diabetes, as defined by absolute insulin deficiency: a systematic review protocol
por: Shields, Beverley M, et al.
Publicado: (2012)

Random non-fasting C-peptide testing can identify patients with insulin-treated type 2 diabetes at high risk of hypoglycaemia
por: Hope, Suzy V., et al.
Publicado: (2017)

Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population
por: Knight, Bridget Ann, et al.
Publicado: (2015)

Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters
por: Knight, Bridget A, et al.
Publicado: (2016)

EDTA Improves Stability of Whole Blood C-Peptide and Insulin to Over 24 Hours at Room Temperature
por: McDonald, Timothy J., et al.
Publicado: (2012)

Assessing newborn body composition using principal components analysis: differences in the determinants of fat and skeletal size
por: Shields, Beverley M, et al.
Publicado: (2006)

Lessons From the Mixed-Meal Tolerance Test: Use of 90-minute and fasting C-peptide in pediatric diabetes
por: Besser, Rachel E.J., et al.
Publicado: (2013)

Response to Comment on: Besser et al. Lessons From the Mixed-Meal Tolerance Test: Use of 90-Minute and Fasting C-Peptide in Pediatric Diabetes. Diabetes Care 2013;36:195–201
por: Shields, Beverley M., et al.
Publicado: (2013)

Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated KCNJ11 neonatal diabetes show predominance of non-K(ATP)-channel pathways
por: Bowman, Pamela, et al.
Publicado: (2019)

Five-Year Follow-Up for Women With Subclinical Hypothyroidism in Pregnancy
por: Shields, Beverley M., et al.
Publicado: (2013)

Can clinical features be used to differentiate type 1 from type 2 diabetes? A systematic review of the literature
por: Shields, Beverley M, et al.
Publicado: (2015)

Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
por: Thomas, Nicholas J, et al.
Publicado: (2018)

Are we missing hypoglycaemia? Elderly patients with insulin-treated diabetes present to primary care frequently with non-specific symptoms associated with hypoglycaemia
por: Hope, Suzy V., et al.
Publicado: (2018)

Screening for neonatal diabetes at day 5 of life using dried blood spot glucose measurement
por: McDonald, Timothy J., et al.
Publicado: (2017)

A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population
por: Freathy, Rachel M, et al.
Publicado: (2006)

Identifying Good Responders to Glucose Lowering Therapy in Type 2 Diabetes: Implications for Stratified Medicine
por: Jones, Angus G., et al.
Publicado: (2014)

Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures
por: Haulder, Maneka, et al.
Publicado: (2022)

HbA1c performs well in monitoring glucose control even in populations with high prevalence of medical conditions that may alter its reliability: the OPTIMAL observational multicenter study
por: Niwaha, Anxious J, et al.
Publicado: (2021)

Identifying routine clinical predictors of non‐adherence to second‐line therapies in type 2 diabetes: A retrospective cohort analysis in a large primary care database
por: Shields, Beverley M., et al.
Publicado: (2019)

Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy
por: Ward, Kirsten J, et al.
Publicado: (2003)

Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study
por: Rodgers, Lauren R., et al.
Publicado: (2021)

High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes
por: McDonald, Tim J., et al.
Publicado: (2011)

The HNF4A R76W mutation causes atypical dominant Fanconi syndrome in addition to a β cell phenotype
por: Hamilton, Alexander J, et al.
Publicado: (2014)

Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data
por: Dennis, John M, et al.
Publicado: (2019)

Exocrine pancreatic dysfunction is common in hepatocyte nuclear factor 1β-associated renal disease and can be symptomatic
por: Clissold, Rhian L, et al.
Publicado: (2018)

South Asian individuals with diabetes who are referred for MODY testing in the UK have a lower mutation pick-up rate than white European people
por: Misra, Shivani, et al.
Publicado: (2016)

Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea‐treated KCNJ11 neonatal diabetes
por: Bowman, Pamela, et al.
Publicado: (2023)

Persistent C‐peptide is associated with reduced hypoglycaemia but not HbA(1c) in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?
por: Marren, S. M., et al.
Publicado: (2019)

TriMaster: randomised double-blind crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as second-line or third-line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on metformin treatment with or without a sulfonylurea—a MASTERMIND study protocol
por: Angwin, Catherine, et al.
Publicado: (2020)

Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?
por: Jones, Angus G., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_f3c8hciudadms6l1shig2p8qn2