Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8(+) T Cells and Efficiently Reduces Chronic Retroviral Loads

Chronic infections with human viruses, such as HIV and HCV, or mouse viruses, such as LCMV or Friend Virus (FV), result in functional exhaustion of CD8(+) T cells. Two main mechanisms have been described that mediate this exhaustion: expression of inhibitory receptors on CD8(+) T cells and expansion...

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Detalles Bibliográficos
Autores principales: Dietze, Kirsten K., Zelinskyy, Gennadiy, Liu, Jia, Kretzmer, Freya, Schimmer, Simone, Dittmer, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855586/
https://www.ncbi.nlm.nih.gov/pubmed/24339778
http://dx.doi.org/10.1371/journal.ppat.1003798

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