Cargando…

STX140, but Not Paclitaxel, Inhibits Mammary Tumour Initiation and Progression in C3(1)/SV40 T/t-Antigen Transgenic Mice

Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX) caused by severe dose limiting toxicities, such as neutropenia and peripheral neuropathy. Consequen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meyer-Losic, Florence, Newman, Simon P., Day, Joanna M., Reed, Michael J., Kasprzyk, Philip G., Purohit, Atul, Foster, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855596/ https://www.ncbi.nlm.nih.gov/pubmed/24324595 http://dx.doi.org/10.1371/journal.pone.0080305

Ejemplares similares

BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure
por: Day, J M, et al.
Publicado: (2009)

Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen
Publicado: (1987)

Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations
por: Siddiqui, Ruqaiyyah, et al.
Publicado: (2023)

Aberrant Proliferation of Differentiating Alveolar Cells Induces Hyperplasia in Resting Mammary Glands of SV40-TAg Transgenic Mice
por: Quante, Timo, et al.
Publicado: (2014)

Hepatocarcinogenesis in Transgenic Mice Carrying Albumin‐promoted SV40 T Antigen Gene
por: Hino, Okio, et al.
Publicado: (1991)

Translatable mRNA for GP140 (a subunit of type VI collagen) is absent in SV40 transformed fibroblasts
Publicado: (1985)

The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer
por: Parsons, M F C, et al.
Publicado: (2008)

SV40 and human mesothelioma
por: Carbone, Michele, et al.
Publicado: (2020)

Expression of a Neuroendocrine Gene Signature in Gastric Tumor Cells from CEA 424-SV40 Large T Antigen-Transgenic Mice Depends on SV40 Large T Antigen
por: Ihler, Fritz, et al.
Publicado: (2012)

SV40: A Human Pathogen?
por: Garcea, Robert L.
Publicado: (2001)

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer
por: Stengel, C, et al.
Publicado: (2014)

Transformation of human cells by SV40 virus.
por: Potter, A. M., et al.
Publicado: (1975)

Modeling of the SV40 DNA Replication Machine
por: Simmons, Daniel T
Publicado: (2012)

Regulation of the promoters in SV40 chromosomes and construction of a substituted SV40 containing aDrosophila hsp70 promoter
por: Beard, P., et al.
Publicado: (1986)

Defective interleukin six expression and responsiveness in human mammary cells transformed by an adeno 5/SV40 hybrid virus.
por: Basolo, F., et al.
Publicado: (1996)

Significance of arming, potentiating and blocking factors as correlates the tumour-host interaction in the hamster SV40 system.
por: Goldrosen, M. H., et al.
Publicado: (1975)

Mechanisms that Determine the Differential Stability of Stx(+) and Stx(−) Lysogens
por: Colon, Michael P., et al.
Publicado: (2016)

Impaired CK1 Delta Activity Attenuates SV40-Induced Cellular Transformation In Vitro and Mouse Mammary Carcinogenesis In Vivo
por: Hirner, Heidrun, et al.
Publicado: (2012)

Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene
por: Nöckel, Jessica, et al.
Publicado: (2006)

AN ELECTRON MICROSCOPE STUDY OF THE DEVELOPMENT OF SV40 VIRUS
por: Granboulan, Nicole, et al.
Publicado: (1963)

Differentiation of human epidermal cells transformed by SV40
Publicado: (1983)

SV40 associated miRNAs are not detectable in mesotheliomas
por: Gee, G V, et al.
Publicado: (2010)

Increasing Evidence for Involvement of SV40 in Human Cancer
por: Butel, Janet S.
Publicado: (2001)

Early Steps of a Thymic Tumor in SV40 Transgenic Mice: Hyperplasia of Medullary Epithelial Cells and Increased Mature Thymocyte Numbers Disturb Thymic Export
por: Nabarra, Bernadette, et al.
Publicado: (2002)

High incidence of SV40-like sequences detection in tumour and peripheral blood cells of Japanese osteosarcoma patients
por: Yamamoto, H, et al.
Publicado: (2000)

Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type 1-Transgenic Liver Cells Using SV40 Large T Antigen
por: Kang, Hee Young, et al.
Publicado: (2017)

DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE
por: Pope, John H., et al.
Publicado: (1964)

Effect of capsid confinement on the chromatin organization of the SV40 minichromosome
por: Saper, Gadiel, et al.
Publicado: (2013)

Failure to induce transplantation immunity to an SV40-induced tumour in hamsters immunized with basic proteins of myelin or malignant tissues.
por: Flavell, D. J., et al.
Publicado: (1978)

Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development
Publicado: (1995)

SV40 intron, a potent strong intron element that effectively increases transgene expression in transfected Chinese hamster ovary cells
por: Xu, Dan‐hua, et al.
Publicado: (2018)

SV40T/E6E7-Induced Proliferation Is Involved in the Activity of E2F3 in Bovine Mammary Epithelial Cells
por: Zhang, Yihui, et al.
Publicado: (2022)

Detection of stx(1) and stx(2) Genes in Pennsylvanian White-Tailed Deer
por: Kistler, Whitney M., et al.
Publicado: (2011)

IN VITRO TRANSFORMATION BY THE ADENOVIRUS-SV40 HYBRID VIRUSES : II. CHARACTERISTICS OF THE TRANSFORMATION OF HAMSTER CELLS BY THE ADENO 2-, ADENO 3-, AND ADENO 12-SV40 VIRUSES
por: Black, Paul H., et al.
Publicado: (1967)

Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-Producing Escherichia coli (STEC) Strain B2F1 in Streptomycin (Str)-Treated Mice
por: McNichol, Beth A., et al.
Publicado: (2021)

Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation
por: Valls, Ester, et al.
Publicado: (2007)

Malignant progression of SV40-immortalised human milk epithelial cells.
por: Yilmaz, A., et al.
Publicado: (1993)

Study of SV40 large T antigen nucleotide specificity for DNA unwinding
por: Wang, Damian, et al.
Publicado: (2017)

Inactivation of Polyomavirus SV40 as Surrogate for Human Papillomaviruses by Chemical Disinfectants
por: Hufbauer, Martin, et al.
Publicado: (2021)

Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice
por: Sheoran, Abhineet, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_csubp339krvhc91hfg8g1fou3b