Mapping the Structural and Dynamical Features of Multiple p53 DNA Binding Domains: Insights into Loop 1 Intrinsic Dynamics

The transcription factor p53 regulates cellular integrity in response to stress. p53 is mutated in more than half of cancerous cells, with a majority of the mutations localized to the DNA binding domain (DBD). In order to map the structural and dynamical features of the DBD, we carried out multiple...

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Detalles Bibliográficos
Autores principales: Lukman, Suryani, Lane, David P., Verma, Chandra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855832/
https://www.ncbi.nlm.nih.gov/pubmed/24324553
http://dx.doi.org/10.1371/journal.pone.0080221

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