Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs

Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are the major source of myofibroblasts in the liver. To date, robust systems to genetically manipulate these cells have not existed. We report that Pdgfrb-...

Descripción completa

Detalles Bibliográficos
Autores principales: Henderson, Neil C, Arnold, Thomas D, Katamura, Yoshio, Giacomini, Marilyn M, Rodriguez, Juan D, McCarty, Joseph H, Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G, Griggs, David W, Prinsen, Michael J, Maher, Jacquelyn J, Iredale, John P, Lacy-Hulbert, Adam, Adams, Ralf H, Sheppard, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855865/
https://www.ncbi.nlm.nih.gov/pubmed/24216753
http://dx.doi.org/10.1038/nm.3282

Ejemplares similares

Ejemplares similares