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Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis

Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large...

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Autores principales: Innaro, Nadia, Succurro, Elena, Tomaino, Giuseppe, Arturi, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855954/
https://www.ncbi.nlm.nih.gov/pubmed/24349811
http://dx.doi.org/10.1155/2013/901246
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author Innaro, Nadia
Succurro, Elena
Tomaino, Giuseppe
Arturi, Franco
author_facet Innaro, Nadia
Succurro, Elena
Tomaino, Giuseppe
Arturi, Franco
author_sort Innaro, Nadia
collection PubMed
description Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease.
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spelling pubmed-38559542013-12-16 Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis Innaro, Nadia Succurro, Elena Tomaino, Giuseppe Arturi, Franco Case Rep Oncol Med Case Report Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease. Hindawi Publishing Corporation 2013 2013-11-18 /pmc/articles/PMC3855954/ /pubmed/24349811 http://dx.doi.org/10.1155/2013/901246 Text en Copyright © 2013 Nadia Innaro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Innaro, Nadia
Succurro, Elena
Tomaino, Giuseppe
Arturi, Franco
Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
title Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
title_full Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
title_fullStr Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
title_full_unstemmed Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
title_short Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
title_sort nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855954/
https://www.ncbi.nlm.nih.gov/pubmed/24349811
http://dx.doi.org/10.1155/2013/901246
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