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Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855954/ https://www.ncbi.nlm.nih.gov/pubmed/24349811 http://dx.doi.org/10.1155/2013/901246 |
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author | Innaro, Nadia Succurro, Elena Tomaino, Giuseppe Arturi, Franco |
author_facet | Innaro, Nadia Succurro, Elena Tomaino, Giuseppe Arturi, Franco |
author_sort | Innaro, Nadia |
collection | PubMed |
description | Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease. |
format | Online Article Text |
id | pubmed-3855954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38559542013-12-16 Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis Innaro, Nadia Succurro, Elena Tomaino, Giuseppe Arturi, Franco Case Rep Oncol Med Case Report Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease. Hindawi Publishing Corporation 2013 2013-11-18 /pmc/articles/PMC3855954/ /pubmed/24349811 http://dx.doi.org/10.1155/2013/901246 Text en Copyright © 2013 Nadia Innaro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Innaro, Nadia Succurro, Elena Tomaino, Giuseppe Arturi, Franco Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
title | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
title_full | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
title_fullStr | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
title_full_unstemmed | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
title_short | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
title_sort | nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855954/ https://www.ncbi.nlm.nih.gov/pubmed/24349811 http://dx.doi.org/10.1155/2013/901246 |
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