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The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population

A recent chordoma cancer genotyping study reveals that the rs2305089, a single nucleotide polymorphism (SNP) located in brachyury gene and a key gene in the development of notochord, is significantly associated with chordoma risk. The brachyury gene is believed to be one of the key genes involved in...

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Autores principales: Wu, Zhen, Wang, Ke, Wang, Liang, Feng, Jie, Hao, Shuyu, Tian, Kaibing, Zhang, Liwei, Jia, Guijun, Wan, Hong, Zhang, Junting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856003/
https://www.ncbi.nlm.nih.gov/pubmed/24232574
http://dx.doi.org/10.3390/ijms141121258
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author Wu, Zhen
Wang, Ke
Wang, Liang
Feng, Jie
Hao, Shuyu
Tian, Kaibing
Zhang, Liwei
Jia, Guijun
Wan, Hong
Zhang, Junting
author_facet Wu, Zhen
Wang, Ke
Wang, Liang
Feng, Jie
Hao, Shuyu
Tian, Kaibing
Zhang, Liwei
Jia, Guijun
Wan, Hong
Zhang, Junting
author_sort Wu, Zhen
collection PubMed
description A recent chordoma cancer genotyping study reveals that the rs2305089, a single nucleotide polymorphism (SNP) located in brachyury gene and a key gene in the development of notochord, is significantly associated with chordoma risk. The brachyury gene is believed to be one of the key genes involved in the pathogenesis of chordoma, a rare primary bone tumor originating along the spinal column or at the base of the skull. The association between the brachyury Gly177Asp single nucleotide polymorphism (SNP) and the risk of skull base chordoma in Chinese populations is currently unknown. We investigated the genotype distribution of this SNP in 65 skull-base chordoma cases and 120 healthy subjects. Comparisons of the genotype distributions and allele frequencies did not reveal any significant difference between the groups. Our data suggest that the brachyury Gly177Asp SNP is not involved in the risks of skull-base chordoma, at least in the Chinese population.
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spelling pubmed-38560032013-12-09 The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population Wu, Zhen Wang, Ke Wang, Liang Feng, Jie Hao, Shuyu Tian, Kaibing Zhang, Liwei Jia, Guijun Wan, Hong Zhang, Junting Int J Mol Sci Article A recent chordoma cancer genotyping study reveals that the rs2305089, a single nucleotide polymorphism (SNP) located in brachyury gene and a key gene in the development of notochord, is significantly associated with chordoma risk. The brachyury gene is believed to be one of the key genes involved in the pathogenesis of chordoma, a rare primary bone tumor originating along the spinal column or at the base of the skull. The association between the brachyury Gly177Asp single nucleotide polymorphism (SNP) and the risk of skull base chordoma in Chinese populations is currently unknown. We investigated the genotype distribution of this SNP in 65 skull-base chordoma cases and 120 healthy subjects. Comparisons of the genotype distributions and allele frequencies did not reveal any significant difference between the groups. Our data suggest that the brachyury Gly177Asp SNP is not involved in the risks of skull-base chordoma, at least in the Chinese population. Molecular Diversity Preservation International (MDPI) 2013-10-25 /pmc/articles/PMC3856003/ /pubmed/24232574 http://dx.doi.org/10.3390/ijms141121258 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Zhen
Wang, Ke
Wang, Liang
Feng, Jie
Hao, Shuyu
Tian, Kaibing
Zhang, Liwei
Jia, Guijun
Wan, Hong
Zhang, Junting
The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population
title The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population
title_full The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population
title_fullStr The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population
title_full_unstemmed The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population
title_short The Brachyury Gly177Asp SNP Is not Associated with a Risk of Skull Base Chordoma in the Chinese Population
title_sort brachyury gly177asp snp is not associated with a risk of skull base chordoma in the chinese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856003/
https://www.ncbi.nlm.nih.gov/pubmed/24232574
http://dx.doi.org/10.3390/ijms141121258
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