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A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a co...

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Autores principales: Heger, Zbynek, Cernei, Natalia, Kudr, Jiri, Gumulec, Jaromir, Blazkova, Iva, Zitka, Ondrej, Eckschlager, Tomas, Stiborova, Marie, Adam, Vojtech, Kizek, Rene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856025/
https://www.ncbi.nlm.nih.gov/pubmed/24185911
http://dx.doi.org/10.3390/ijms141121629
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author Heger, Zbynek
Cernei, Natalia
Kudr, Jiri
Gumulec, Jaromir
Blazkova, Iva
Zitka, Ondrej
Eckschlager, Tomas
Stiborova, Marie
Adam, Vojtech
Kizek, Rene
author_facet Heger, Zbynek
Cernei, Natalia
Kudr, Jiri
Gumulec, Jaromir
Blazkova, Iva
Zitka, Ondrej
Eckschlager, Tomas
Stiborova, Marie
Adam, Vojtech
Kizek, Rene
author_sort Heger, Zbynek
collection PubMed
description Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, β-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.
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spelling pubmed-38560252013-12-09 A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin Heger, Zbynek Cernei, Natalia Kudr, Jiri Gumulec, Jaromir Blazkova, Iva Zitka, Ondrej Eckschlager, Tomas Stiborova, Marie Adam, Vojtech Kizek, Rene Int J Mol Sci Article Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, β-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium. Molecular Diversity Preservation International (MDPI) 2013-10-31 /pmc/articles/PMC3856025/ /pubmed/24185911 http://dx.doi.org/10.3390/ijms141121629 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Heger, Zbynek
Cernei, Natalia
Kudr, Jiri
Gumulec, Jaromir
Blazkova, Iva
Zitka, Ondrej
Eckschlager, Tomas
Stiborova, Marie
Adam, Vojtech
Kizek, Rene
A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
title A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
title_full A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
title_fullStr A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
title_full_unstemmed A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
title_short A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
title_sort novel insight into the cardiotoxicity of antineoplastic drug doxorubicin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856025/
https://www.ncbi.nlm.nih.gov/pubmed/24185911
http://dx.doi.org/10.3390/ijms141121629
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