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Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis

The liver is crucial for human life, and the health of this organ often mirrors the health of the individual. The liver can be the target of several diseases, the most prevalent of which, as a consequence of development and changes in human lifestyles, is the nonalcoholic fatty liver disease (NAFLD)...

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Autores principales: Arciello, Mario, Gori, Manuele, Maggio, Roberta, Barbaro, Barbara, Tarocchi, Mirko, Galli, Andrea, Balsano, Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856051/
https://www.ncbi.nlm.nih.gov/pubmed/24213605
http://dx.doi.org/10.3390/ijms141122052
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author Arciello, Mario
Gori, Manuele
Maggio, Roberta
Barbaro, Barbara
Tarocchi, Mirko
Galli, Andrea
Balsano, Clara
author_facet Arciello, Mario
Gori, Manuele
Maggio, Roberta
Barbaro, Barbara
Tarocchi, Mirko
Galli, Andrea
Balsano, Clara
author_sort Arciello, Mario
collection PubMed
description The liver is crucial for human life, and the health of this organ often mirrors the health of the individual. The liver can be the target of several diseases, the most prevalent of which, as a consequence of development and changes in human lifestyles, is the nonalcoholic fatty liver disease (NAFLD). NAFLD is a multifactorial disease that embraces many histo-pathologic conditions and is highly linked to metabolic derangements. Technological progress and industrialization have also had the consequence of releasing pollutants in the environment, for instance pesticides or solvents, as well as by-products of discharge, such as the particulate matter. In the last decade, a growing body of evidence has emerged, shedding light on the potential impact of environmental pollutants on liver health and, in particular, on NAFLD occurrence. These contaminants have a great steatogenic potential and need to be considered as tangible NAFLD risk factors. There is an urgent need for a deeper comprehension of their molecular mechanisms of action, as well as for new lines of intervention to reduce their worldwide diffusion. This review wishes to sensitize the community to the effects of several environmental pollutants on liver health.
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spelling pubmed-38560512013-12-09 Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis Arciello, Mario Gori, Manuele Maggio, Roberta Barbaro, Barbara Tarocchi, Mirko Galli, Andrea Balsano, Clara Int J Mol Sci Review The liver is crucial for human life, and the health of this organ often mirrors the health of the individual. The liver can be the target of several diseases, the most prevalent of which, as a consequence of development and changes in human lifestyles, is the nonalcoholic fatty liver disease (NAFLD). NAFLD is a multifactorial disease that embraces many histo-pathologic conditions and is highly linked to metabolic derangements. Technological progress and industrialization have also had the consequence of releasing pollutants in the environment, for instance pesticides or solvents, as well as by-products of discharge, such as the particulate matter. In the last decade, a growing body of evidence has emerged, shedding light on the potential impact of environmental pollutants on liver health and, in particular, on NAFLD occurrence. These contaminants have a great steatogenic potential and need to be considered as tangible NAFLD risk factors. There is an urgent need for a deeper comprehension of their molecular mechanisms of action, as well as for new lines of intervention to reduce their worldwide diffusion. This review wishes to sensitize the community to the effects of several environmental pollutants on liver health. Molecular Diversity Preservation International (MDPI) 2013-11-07 /pmc/articles/PMC3856051/ /pubmed/24213605 http://dx.doi.org/10.3390/ijms141122052 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Arciello, Mario
Gori, Manuele
Maggio, Roberta
Barbaro, Barbara
Tarocchi, Mirko
Galli, Andrea
Balsano, Clara
Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis
title Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis
title_full Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis
title_fullStr Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis
title_full_unstemmed Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis
title_short Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis
title_sort environmental pollution: a tangible risk for nafld pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856051/
https://www.ncbi.nlm.nih.gov/pubmed/24213605
http://dx.doi.org/10.3390/ijms141122052
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