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Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients

Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in...

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Autores principales: Wang, Hsiang-Ling, Hsiao, Pei-Ching, Tsai, Hsiu-Ting, Yeh, Chao-Bin, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856092/
https://www.ncbi.nlm.nih.gov/pubmed/24256818
http://dx.doi.org/10.3390/ijms141122817
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author Wang, Hsiang-Ling
Hsiao, Pei-Ching
Tsai, Hsiu-Ting
Yeh, Chao-Bin
Yang, Shun-Fa
author_facet Wang, Hsiang-Ling
Hsiao, Pei-Ching
Tsai, Hsiu-Ting
Yeh, Chao-Bin
Yang, Shun-Fa
author_sort Wang, Hsiang-Ling
collection PubMed
description Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.
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spelling pubmed-38560922013-12-09 Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients Wang, Hsiang-Ling Hsiao, Pei-Ching Tsai, Hsiu-Ting Yeh, Chao-Bin Yang, Shun-Fa Int J Mol Sci Article Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies. Molecular Diversity Preservation International (MDPI) 2013-11-19 /pmc/articles/PMC3856092/ /pubmed/24256818 http://dx.doi.org/10.3390/ijms141122817 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Hsiang-Ling
Hsiao, Pei-Ching
Tsai, Hsiu-Ting
Yeh, Chao-Bin
Yang, Shun-Fa
Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients
title Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients
title_full Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients
title_fullStr Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients
title_full_unstemmed Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients
title_short Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients
title_sort usefulness of plasma ykl-40 in management of community-acquired pneumonia severity in patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856092/
https://www.ncbi.nlm.nih.gov/pubmed/24256818
http://dx.doi.org/10.3390/ijms141122817
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