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Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients
Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856092/ https://www.ncbi.nlm.nih.gov/pubmed/24256818 http://dx.doi.org/10.3390/ijms141122817 |
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author | Wang, Hsiang-Ling Hsiao, Pei-Ching Tsai, Hsiu-Ting Yeh, Chao-Bin Yang, Shun-Fa |
author_facet | Wang, Hsiang-Ling Hsiao, Pei-Ching Tsai, Hsiu-Ting Yeh, Chao-Bin Yang, Shun-Fa |
author_sort | Wang, Hsiang-Ling |
collection | PubMed |
description | Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies. |
format | Online Article Text |
id | pubmed-3856092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-38560922013-12-09 Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients Wang, Hsiang-Ling Hsiao, Pei-Ching Tsai, Hsiu-Ting Yeh, Chao-Bin Yang, Shun-Fa Int J Mol Sci Article Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies. Molecular Diversity Preservation International (MDPI) 2013-11-19 /pmc/articles/PMC3856092/ /pubmed/24256818 http://dx.doi.org/10.3390/ijms141122817 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Wang, Hsiang-Ling Hsiao, Pei-Ching Tsai, Hsiu-Ting Yeh, Chao-Bin Yang, Shun-Fa Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients |
title | Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients |
title_full | Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients |
title_fullStr | Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients |
title_full_unstemmed | Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients |
title_short | Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients |
title_sort | usefulness of plasma ykl-40 in management of community-acquired pneumonia severity in patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856092/ https://www.ncbi.nlm.nih.gov/pubmed/24256818 http://dx.doi.org/10.3390/ijms141122817 |
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