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Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest or slow its progression. Current pharmacologic treatments such as analgesics may improve pain relief but do not alter OA disease progression....

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Autores principales: Leong, Daniel J., Choudhury, Marwa, Hirsh, David M., Hardin, John A., Cobelli, Neil J., Sun, Hui B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856106/
https://www.ncbi.nlm.nih.gov/pubmed/24284399
http://dx.doi.org/10.3390/ijms141123063
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author Leong, Daniel J.
Choudhury, Marwa
Hirsh, David M.
Hardin, John A.
Cobelli, Neil J.
Sun, Hui B.
author_facet Leong, Daniel J.
Choudhury, Marwa
Hirsh, David M.
Hardin, John A.
Cobelli, Neil J.
Sun, Hui B.
author_sort Leong, Daniel J.
collection PubMed
description Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest or slow its progression. Current pharmacologic treatments such as analgesics may improve pain relief but do not alter OA disease progression. Prolonged consumption of these drugs can result in severe adverse effects. Given the nature of OA, life-long treatment will likely be required to arrest or slow its progression. Consequently, there is an urgent need for OA disease-modifying therapies which also improve symptoms and are safe for clinical use over long periods of time. Nutraceuticals—food or food products that provide medical or health benefits, including the prevention and/or treatment of a disease—offer not only favorable safety profiles, but may exert disease- and symptom-modification effects in OA. Forty-seven percent of OA patients use alternative medications, including nutraceuticals. This review will overview the efficacy and mechanism of action of commonly used nutraceuticals, discuss recent experimental and clinical data on the effects of select nutraceuticals, such as phytoflavonoids, polyphenols, and bioflavonoids on OA, and highlight their known molecular actions and limitations of their current use. We will conclude with a proposed novel nutraceutical-based molecular targeting strategy for chondroprotection and OA treatment.
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spelling pubmed-38561062013-12-09 Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis Leong, Daniel J. Choudhury, Marwa Hirsh, David M. Hardin, John A. Cobelli, Neil J. Sun, Hui B. Int J Mol Sci Review Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest or slow its progression. Current pharmacologic treatments such as analgesics may improve pain relief but do not alter OA disease progression. Prolonged consumption of these drugs can result in severe adverse effects. Given the nature of OA, life-long treatment will likely be required to arrest or slow its progression. Consequently, there is an urgent need for OA disease-modifying therapies which also improve symptoms and are safe for clinical use over long periods of time. Nutraceuticals—food or food products that provide medical or health benefits, including the prevention and/or treatment of a disease—offer not only favorable safety profiles, but may exert disease- and symptom-modification effects in OA. Forty-seven percent of OA patients use alternative medications, including nutraceuticals. This review will overview the efficacy and mechanism of action of commonly used nutraceuticals, discuss recent experimental and clinical data on the effects of select nutraceuticals, such as phytoflavonoids, polyphenols, and bioflavonoids on OA, and highlight their known molecular actions and limitations of their current use. We will conclude with a proposed novel nutraceutical-based molecular targeting strategy for chondroprotection and OA treatment. Molecular Diversity Preservation International (MDPI) 2013-11-21 /pmc/articles/PMC3856106/ /pubmed/24284399 http://dx.doi.org/10.3390/ijms141123063 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Leong, Daniel J.
Choudhury, Marwa
Hirsh, David M.
Hardin, John A.
Cobelli, Neil J.
Sun, Hui B.
Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis
title Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis
title_full Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis
title_fullStr Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis
title_full_unstemmed Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis
title_short Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis
title_sort nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856106/
https://www.ncbi.nlm.nih.gov/pubmed/24284399
http://dx.doi.org/10.3390/ijms141123063
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