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Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation
BACKGROUND: Former studies showed possible interrelationship between altered ventricular filling patterns and atrial fibrillation (AF). HYPOTHESIS: Long term persistent AF has a negative impact on left ventricular filling in patients with preserved ejection fraction of left ventricle. METHODS: Our s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856378/ https://www.ncbi.nlm.nih.gov/pubmed/24324364 http://dx.doi.org/10.7150/ijms.6613 |
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author | Naji, Franjo Pagliaruzzi, Mihael Penko, Meta Kanic, Vojko Vokac, Damijan |
author_facet | Naji, Franjo Pagliaruzzi, Mihael Penko, Meta Kanic, Vojko Vokac, Damijan |
author_sort | Naji, Franjo |
collection | PubMed |
description | BACKGROUND: Former studies showed possible interrelationship between altered ventricular filling patterns and atrial fibrillation (AF). HYPOTHESIS: Long term persistent AF has a negative impact on left ventricular filling in patients with preserved ejection fraction of left ventricle. METHODS: Our study was designed as a prospective case control study. We included 40 patients with persistent AF and preserved ejection fraction after successful electrical cardioversion and 43 control patients. Persistent AF was defined as AF lasting more than 4 weeks. Cardiac ultrasound was performed in all patients 24 hours after the procedure. Appropriate mitral flow and tissue Doppler velocities as well as standard echocardiographic measurements were obtained. RESULTS: There were no significant differences between both groups' parameters regarding age, sex, commorbidities or drug therapy. Analysis of mitral flow velocities showed significant increase of E value in AF group (0.96±0.27 vs.0.70±0.14; p = 0.001). Tissue Doppler measurements didn't reveal any differences in early diastolic movement, however there was a statistically significant difference in E/Em values of both groups, respectively (12.0±4.0 vs. 9.0±2.1; p= 0.001). CONCLUSION: Our study shows that in patients with preserved systolic function and persistent AF shortly after cardioversion diastolic ventricular filling patterns are altered mainly due to increased left atrial pressure and not due to impaired diastolic relaxation of left ventricle. Further studies are needed in order to define the interplay between diminished atrial function and impaired ventricular filling. |
format | Online Article Text |
id | pubmed-3856378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-38563782013-12-09 Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation Naji, Franjo Pagliaruzzi, Mihael Penko, Meta Kanic, Vojko Vokac, Damijan Int J Med Sci Research Paper BACKGROUND: Former studies showed possible interrelationship between altered ventricular filling patterns and atrial fibrillation (AF). HYPOTHESIS: Long term persistent AF has a negative impact on left ventricular filling in patients with preserved ejection fraction of left ventricle. METHODS: Our study was designed as a prospective case control study. We included 40 patients with persistent AF and preserved ejection fraction after successful electrical cardioversion and 43 control patients. Persistent AF was defined as AF lasting more than 4 weeks. Cardiac ultrasound was performed in all patients 24 hours after the procedure. Appropriate mitral flow and tissue Doppler velocities as well as standard echocardiographic measurements were obtained. RESULTS: There were no significant differences between both groups' parameters regarding age, sex, commorbidities or drug therapy. Analysis of mitral flow velocities showed significant increase of E value in AF group (0.96±0.27 vs.0.70±0.14; p = 0.001). Tissue Doppler measurements didn't reveal any differences in early diastolic movement, however there was a statistically significant difference in E/Em values of both groups, respectively (12.0±4.0 vs. 9.0±2.1; p= 0.001). CONCLUSION: Our study shows that in patients with preserved systolic function and persistent AF shortly after cardioversion diastolic ventricular filling patterns are altered mainly due to increased left atrial pressure and not due to impaired diastolic relaxation of left ventricle. Further studies are needed in order to define the interplay between diminished atrial function and impaired ventricular filling. Ivyspring International Publisher 2013-11-20 /pmc/articles/PMC3856378/ /pubmed/24324364 http://dx.doi.org/10.7150/ijms.6613 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Research Paper Naji, Franjo Pagliaruzzi, Mihael Penko, Meta Kanic, Vojko Vokac, Damijan Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation |
title | Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation |
title_full | Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation |
title_fullStr | Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation |
title_full_unstemmed | Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation |
title_short | Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation |
title_sort | changes in left ventricular filling in patients with persistent atrial fibrillation |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856378/ https://www.ncbi.nlm.nih.gov/pubmed/24324364 http://dx.doi.org/10.7150/ijms.6613 |
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