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Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants

BACKGROUND: Selective pressure from either the immune response or the use of nucleoside analogs in antiviral therapy could be driving the emergence of HBV mutants. Because of the overlap of the open reading frame (ORF) S for the HBsAg and ORF P for viral polymerase, rtM204I and rtM204V mutations in...

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Detalles Bibliográficos
Autores principales:	Zhang, Mingshun, Ge, Guohong, Yang, Yonglin, Cai, Xubing, Fu, Qiang, Cai, Jie, Huang, Zuhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856468/ https://www.ncbi.nlm.nih.gov/pubmed/24053482 http://dx.doi.org/10.1186/1743-422X-10-292

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