RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients

BACKGROUND: A major obstacle in treating colorectal cancer (CRC) is the acquired resistance to chemotherapeutic agents. An important protein in the regulation of cancer cell death and clinical outcome is Raf kinase inhibitor protein (RKIP). In contrast, activated signal transducer and activator of t...

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Detalles Bibliográficos
Autores principales: Cross-Knorr, Sam, Lu, Shaolei, Perez, Kimberly, Guevara, Sara, Brilliant, Kate, Pisano, Claudio, Quesenberry, Peter J, Resnick, Murray B, Chatterjee, Devasis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856511/
https://www.ncbi.nlm.nih.gov/pubmed/24098947
http://dx.doi.org/10.1186/1471-2407-13-463

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