Cargando…

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers

BACKGROUND: The members of MRE11/RAD50/NBN (MRN) protein complex participates in DNA double-strand break repair and DNA-damage checkpoint activation. We have previously shown that the p.I171V NBN gene mutation may contribute to the development of laryngeal cancer. This study tested the hypothesis th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ziółkowska-Suchanek, Iwona, Mosor, Maria, Wierzbicka, Małgorzata, Rydzanicz, Małgorzata, Baranowska, Marta, Nowak, Jerzy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856607/ https://www.ncbi.nlm.nih.gov/pubmed/24079363 http://dx.doi.org/10.1186/1476-4598-12-113

Ejemplares similares

Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia
por: Mosor, Maria, et al.
Publicado: (2013)

Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population
por: Podralska, Marta, et al.
Publicado: (2018)

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
por: Situ, Yiling, et al.
Publicado: (2019)

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells
por: McPherson, Matthew T., et al.
Publicado: (2020)

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex
por: Otahalova, Barbora, et al.
Publicado: (2023)

Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer
por: Brandt, Simone, et al.
Publicado: (2017)

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis
por: Ho, Vincent, et al.
Publicado: (2018)

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
por: Lee, Ji-Hoon, et al.
Publicado: (2013)

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks
por: Lee, Joon, et al.
Publicado: (2013)

The most frequent Polish ATM mutations are not susceptibility factors for tobacco-related cancers
por: Podralska, Marta, et al.
Publicado: (2020)

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex
por: Möckel, Carolin, et al.
Publicado: (2012)

The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions
por: Hohl, Marcel, et al.
Publicado: (2011)

Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex
por: Vertemara, Jacopo, et al.
Publicado: (2023)

Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma
por: Schuetz, Johanna M, et al.
Publicado: (2009)

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex
por: Chen, Yu-Jie, et al.
Publicado: (2016)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens
por: Kamisugi, Yasuko, et al.
Publicado: (2012)

The Mre11-Rad50-Xrs2 Complex Is Required for Yeast DNA Postreplication Repair
por: Ball, Lindsay G., et al.
Publicado: (2014)

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex
por: Lim, Chew Theng, et al.
Publicado: (2015)

PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
por: Grygiel-Górniak, Bogna, et al.
Publicado: (2018)

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency
por: Mariggiò, Giuseppe, et al.
Publicado: (2017)

Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases
por: Ziółkowska-Suchanek, Iwona, et al.
Publicado: (2015)

A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair
por: Steininger, Sylvia, et al.
Publicado: (2010)

The ATP-bound conformation of the Mre11–Rad50 complex is essential for Tel1/ATM activation
por: Cassani, Corinne, et al.
Publicado: (2019)

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex
por: Rahman, Samiur, et al.
Publicado: (2020)

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers
por: Alblihy, Adel, et al.
Publicado: (2021)

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair
por: Williams, Gareth J., et al.
Publicado: (2011)

DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcanii
por: Delmas, Stéphane, et al.
Publicado: (2013)

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
por: Takeda, Shunichi, et al.
Publicado: (2016)

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
por: Bian, Lei, et al.
Publicado: (2019)

FAM13A as a Novel Hypoxia-Induced Gene in Non-Small Cell Lung Cancer
por: Ziółkowska-Suchanek, Iwona, et al.
Publicado: (2017)

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
por: Jazayeri, Ali, et al.
Publicado: (2008)

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
por: Spycher, Christoph, et al.
Publicado: (2008)

Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmids
por: Yoshida, Takashi, et al.
Publicado: (2011)

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis
por: Taylor, Elaine M., et al.
Publicado: (2010)

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles
por: Wang, Weibin, et al.
Publicado: (2017)

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1
por: Limbo, Oliver, et al.
Publicado: (2018)

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism
por: Laffitte, Marie-Claude N., et al.
Publicado: (2016)

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
por: Chang, Emily Yun-Chia, et al.
Publicado: (2019)

Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients
por: Djuzenova, C, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_v1mp2p49469ovf5h8qgl44ukil