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Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting
PURPOSE: Lifestyle factors may influence observed associations between proton pump inhibitor (PPI) usage and health outcomes. The aim of the study reported here was to examine characteristics and differences in lifestyle among PPI users and nonusers. METHODS: This cross-sectional study utilized data...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857010/ https://www.ncbi.nlm.nih.gov/pubmed/24348070 http://dx.doi.org/10.2147/CLEP.S49354 |
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author | Hvid-Jensen, Frederik Nielsen, Rikke B Pedersen, Lars Funch-Jensen, Peter Drewes, Asbjørn Mohr Larsen, Finn B Thomsen, Reimar W |
author_facet | Hvid-Jensen, Frederik Nielsen, Rikke B Pedersen, Lars Funch-Jensen, Peter Drewes, Asbjørn Mohr Larsen, Finn B Thomsen, Reimar W |
author_sort | Hvid-Jensen, Frederik |
collection | PubMed |
description | PURPOSE: Lifestyle factors may influence observed associations between proton pump inhibitor (PPI) usage and health outcomes. The aim of the study reported here was to examine characteristics and differences in lifestyle among PPI users and nonusers. METHODS: This cross-sectional study utilized data from a 2006 population-based health survey of 21,637 persons in the Central Danish Region. All persons using prescribed PPIs were identified through linkage to a population-based prescription database. Biometric measures and prevalence of smoking, excessive alcohol consumption, diet, and physical exercise were analyzed, comparing PPI users with nonusers. RESULTS: Among 10,129 (46.8%) male and 11,508 (53.2%) female survey respondents, 1,356 (13.4%) males and 1,691 (14.7%) females reported ever use of PPIs. PPI users were more obese (16.7%) than nonusers (13.1%), with an age- and sex-standardized prevalence ratio (PR) of 1.3 (95% confidence interval [CI]: 1.2–1.4). The prevalence of smokers was also higher in the PPI group (26.2% vs 22.3% [PR =1.2, 95% CI: 1.1–1.3]), as was the prevalence of ex-smokers (41.0% vs 32.0% [PR =1.2, 95% CI: 1.1–1.2]). Unhealthy diet was slightly more common among PPI users than among nonusers (15.4% vs 13.0%), with a PR of 1.2 (95% CI: 1.1–1.3). Physical exercise level and alcohol consumption were similar in the two groups. Hospital-diagnosed comorbidity was observed in 35% of PPI users (a Charlson Comorbidity Index score of 1 or more) compared with only 15% among nonusers. CONCLUSION: PPI users are more obese, smoke more, and have significantly more comorbidities than PPI nonusers. These data are important when evaluating unmeasured confounding in observational studies of PPI effects. |
format | Online Article Text |
id | pubmed-3857010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38570102013-12-12 Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting Hvid-Jensen, Frederik Nielsen, Rikke B Pedersen, Lars Funch-Jensen, Peter Drewes, Asbjørn Mohr Larsen, Finn B Thomsen, Reimar W Clin Epidemiol Original Research PURPOSE: Lifestyle factors may influence observed associations between proton pump inhibitor (PPI) usage and health outcomes. The aim of the study reported here was to examine characteristics and differences in lifestyle among PPI users and nonusers. METHODS: This cross-sectional study utilized data from a 2006 population-based health survey of 21,637 persons in the Central Danish Region. All persons using prescribed PPIs were identified through linkage to a population-based prescription database. Biometric measures and prevalence of smoking, excessive alcohol consumption, diet, and physical exercise were analyzed, comparing PPI users with nonusers. RESULTS: Among 10,129 (46.8%) male and 11,508 (53.2%) female survey respondents, 1,356 (13.4%) males and 1,691 (14.7%) females reported ever use of PPIs. PPI users were more obese (16.7%) than nonusers (13.1%), with an age- and sex-standardized prevalence ratio (PR) of 1.3 (95% confidence interval [CI]: 1.2–1.4). The prevalence of smokers was also higher in the PPI group (26.2% vs 22.3% [PR =1.2, 95% CI: 1.1–1.3]), as was the prevalence of ex-smokers (41.0% vs 32.0% [PR =1.2, 95% CI: 1.1–1.2]). Unhealthy diet was slightly more common among PPI users than among nonusers (15.4% vs 13.0%), with a PR of 1.2 (95% CI: 1.1–1.3). Physical exercise level and alcohol consumption were similar in the two groups. Hospital-diagnosed comorbidity was observed in 35% of PPI users (a Charlson Comorbidity Index score of 1 or more) compared with only 15% among nonusers. CONCLUSION: PPI users are more obese, smoke more, and have significantly more comorbidities than PPI nonusers. These data are important when evaluating unmeasured confounding in observational studies of PPI effects. Dove Medical Press 2013-12-04 /pmc/articles/PMC3857010/ /pubmed/24348070 http://dx.doi.org/10.2147/CLEP.S49354 Text en © 2013 Hvid-Jensen et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed. |
spellingShingle | Original Research Hvid-Jensen, Frederik Nielsen, Rikke B Pedersen, Lars Funch-Jensen, Peter Drewes, Asbjørn Mohr Larsen, Finn B Thomsen, Reimar W Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting |
title | Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting |
title_full | Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting |
title_fullStr | Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting |
title_full_unstemmed | Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting |
title_short | Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting |
title_sort | lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857010/ https://www.ncbi.nlm.nih.gov/pubmed/24348070 http://dx.doi.org/10.2147/CLEP.S49354 |
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