Cargando…

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age (6.8%–18%), is among the most common causes of infertility due to ovulation factors, and accounts for 55%–70% of infertility cases caused by chronic anovulation. In this study, we used a c...

Descripción completa

Detalles Bibliográficos
Autores principales: Hajishafiha, Masomeh, Dehghan, Meisam, Kiarang, Nazila, Sadegh-Asadi, Nahideh, Shayegh, Seyed Navid, Ghasemi-Rad, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857067/
https://www.ncbi.nlm.nih.gov/pubmed/24348019
http://dx.doi.org/10.2147/DDDT.S50972
_version_ 1782295112545468416
author Hajishafiha, Masomeh
Dehghan, Meisam
Kiarang, Nazila
Sadegh-Asadi, Nahideh
Shayegh, Seyed Navid
Ghasemi-Rad, Mohammad
author_facet Hajishafiha, Masomeh
Dehghan, Meisam
Kiarang, Nazila
Sadegh-Asadi, Nahideh
Shayegh, Seyed Navid
Ghasemi-Rad, Mohammad
author_sort Hajishafiha, Masomeh
collection PubMed
description BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age (6.8%–18%), is among the most common causes of infertility due to ovulation factors, and accounts for 55%–70% of infertility cases caused by chronic anovulation. In this study, we used a combination of letrozole and clomiphene in patients resistant to both drugs individually, and studied the effects of this combination in ovulation and pregnancy in resistant PCOS patients. METHODS: The study population included infertile couples diagnosed as PCOS in the wife. The women used clomiphene for at least six cycles in order to ovulate after failure to form the dominant follicle, and were then put on letrozole for four cycles. Patients who were unable to form the dominant follicle were enrolled on letrozole and clomiphene combination therapy. RESULTS: One hundred enrolled patients underwent 257 cycles of a combination of letrozole and clomiphene, in which 213 were able to form the dominant follicle (82.9%) and 44 were unable to do so (17.1%). The number of mature follicles was 2.3±1.1. The mean endometrial thickness in patients on the day of human chorionic gonadotropin administration was 8.17±1.3 mm. The pregnancy rate was 42%. CONCLUSION: According to the results of this study, it can be proposed that in PCOS patients resistant to clomiphene and letrozole used as single agents, a combination of the two drugs can be administered before using more aggressive treatment that may have severe complications or surgery. This combination may also be used as a first-line therapy to induce ovulation in severe cases of PCOS in order to save time and expense.
format Online
Article
Text
id pubmed-3857067
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-38570672013-12-12 Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome Hajishafiha, Masomeh Dehghan, Meisam Kiarang, Nazila Sadegh-Asadi, Nahideh Shayegh, Seyed Navid Ghasemi-Rad, Mohammad Drug Des Devel Ther Original Research BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age (6.8%–18%), is among the most common causes of infertility due to ovulation factors, and accounts for 55%–70% of infertility cases caused by chronic anovulation. In this study, we used a combination of letrozole and clomiphene in patients resistant to both drugs individually, and studied the effects of this combination in ovulation and pregnancy in resistant PCOS patients. METHODS: The study population included infertile couples diagnosed as PCOS in the wife. The women used clomiphene for at least six cycles in order to ovulate after failure to form the dominant follicle, and were then put on letrozole for four cycles. Patients who were unable to form the dominant follicle were enrolled on letrozole and clomiphene combination therapy. RESULTS: One hundred enrolled patients underwent 257 cycles of a combination of letrozole and clomiphene, in which 213 were able to form the dominant follicle (82.9%) and 44 were unable to do so (17.1%). The number of mature follicles was 2.3±1.1. The mean endometrial thickness in patients on the day of human chorionic gonadotropin administration was 8.17±1.3 mm. The pregnancy rate was 42%. CONCLUSION: According to the results of this study, it can be proposed that in PCOS patients resistant to clomiphene and letrozole used as single agents, a combination of the two drugs can be administered before using more aggressive treatment that may have severe complications or surgery. This combination may also be used as a first-line therapy to induce ovulation in severe cases of PCOS in order to save time and expense. Dove Medical Press 2013-12-03 /pmc/articles/PMC3857067/ /pubmed/24348019 http://dx.doi.org/10.2147/DDDT.S50972 Text en © 2013 Hajishafiha et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Hajishafiha, Masomeh
Dehghan, Meisam
Kiarang, Nazila
Sadegh-Asadi, Nahideh
Shayegh, Seyed Navid
Ghasemi-Rad, Mohammad
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
title Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
title_full Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
title_fullStr Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
title_full_unstemmed Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
title_short Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
title_sort combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857067/
https://www.ncbi.nlm.nih.gov/pubmed/24348019
http://dx.doi.org/10.2147/DDDT.S50972
work_keys_str_mv AT hajishafihamasomeh combinedletrozoleandclomipheneversusletrozoleandclomiphenealoneininfertilepatientswithpolycysticovarysyndrome
AT dehghanmeisam combinedletrozoleandclomipheneversusletrozoleandclomiphenealoneininfertilepatientswithpolycysticovarysyndrome
AT kiarangnazila combinedletrozoleandclomipheneversusletrozoleandclomiphenealoneininfertilepatientswithpolycysticovarysyndrome
AT sadeghasadinahideh combinedletrozoleandclomipheneversusletrozoleandclomiphenealoneininfertilepatientswithpolycysticovarysyndrome
AT shayeghseyednavid combinedletrozoleandclomipheneversusletrozoleandclomiphenealoneininfertilepatientswithpolycysticovarysyndrome
AT ghasemiradmohammad combinedletrozoleandclomipheneversusletrozoleandclomiphenealoneininfertilepatientswithpolycysticovarysyndrome