Fliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium

Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-sensitive liposomes containing the amphiphile (1) w...

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Detalles Bibliográficos
Autores principales: Samoshina, Nataliya M., Liu, Xin, Brazdova, Barbora, Franz, Andreas H., Samoshin, Vyacheslav V., Guo, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857072/
https://www.ncbi.nlm.nih.gov/pubmed/24310586
http://dx.doi.org/10.3390/pharmaceutics3030379

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