Cargando…

Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies

The application of twin screw extrusion (TSE) as a scalable and green process for the manufacture of cocrystals was investigated. Four model cocrystal forming systems, Caffeine-Oxalic acid, Nicotinamide-trans cinnamic acid, Carbamazepine-Saccharin, and Theophylline-Citric acid, were selected for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Daurio, Dominick, Medina, Cesar, Saw, Robert, Nagapudi, Karthik, Alvarez-Núñez, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857084/
https://www.ncbi.nlm.nih.gov/pubmed/24310598
http://dx.doi.org/10.3390/pharmaceutics3030582
_version_ 1782295116402130944
author Daurio, Dominick
Medina, Cesar
Saw, Robert
Nagapudi, Karthik
Alvarez-Núñez, Fernando
author_facet Daurio, Dominick
Medina, Cesar
Saw, Robert
Nagapudi, Karthik
Alvarez-Núñez, Fernando
author_sort Daurio, Dominick
collection PubMed
description The application of twin screw extrusion (TSE) as a scalable and green process for the manufacture of cocrystals was investigated. Four model cocrystal forming systems, Caffeine-Oxalic acid, Nicotinamide-trans cinnamic acid, Carbamazepine-Saccharin, and Theophylline-Citric acid, were selected for the study. The parameters of the extrusion process that influenced cocrystal formation were examined. TSE was found to be an effective method to make cocrystals for all four systems studied. It was demonstrated that temperature and extent of mixing in the extruder were the primary process parameters that influenced extent of conversion to the cocrystal in neat TSE experiments. In addition to neat extrusion, liquid-assisted TSE was also demonstrated for the first time as a viable process for making cocrystals. Notably, the use of catalytic amount of benign solvents led to a lowering of processing temperatures required to form the cocrystal in the extruder. TSE should be considered as an efficient, scalable, and environmentally friendly process for the manufacture of cocrystals with little to no solvent requirements.
format Online
Article
Text
id pubmed-3857084
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-38570842013-12-16 Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies Daurio, Dominick Medina, Cesar Saw, Robert Nagapudi, Karthik Alvarez-Núñez, Fernando Pharmaceutics Article The application of twin screw extrusion (TSE) as a scalable and green process for the manufacture of cocrystals was investigated. Four model cocrystal forming systems, Caffeine-Oxalic acid, Nicotinamide-trans cinnamic acid, Carbamazepine-Saccharin, and Theophylline-Citric acid, were selected for the study. The parameters of the extrusion process that influenced cocrystal formation were examined. TSE was found to be an effective method to make cocrystals for all four systems studied. It was demonstrated that temperature and extent of mixing in the extruder were the primary process parameters that influenced extent of conversion to the cocrystal in neat TSE experiments. In addition to neat extrusion, liquid-assisted TSE was also demonstrated for the first time as a viable process for making cocrystals. Notably, the use of catalytic amount of benign solvents led to a lowering of processing temperatures required to form the cocrystal in the extruder. TSE should be considered as an efficient, scalable, and environmentally friendly process for the manufacture of cocrystals with little to no solvent requirements. MDPI 2011-08-31 /pmc/articles/PMC3857084/ /pubmed/24310598 http://dx.doi.org/10.3390/pharmaceutics3030582 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Daurio, Dominick
Medina, Cesar
Saw, Robert
Nagapudi, Karthik
Alvarez-Núñez, Fernando
Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies
title Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies
title_full Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies
title_fullStr Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies
title_full_unstemmed Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies
title_short Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies
title_sort application of twin screw extrusion in the manufacture of cocrystals, part i: four case studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857084/
https://www.ncbi.nlm.nih.gov/pubmed/24310598
http://dx.doi.org/10.3390/pharmaceutics3030582
work_keys_str_mv AT dauriodominick applicationoftwinscrewextrusioninthemanufactureofcocrystalspartifourcasestudies
AT medinacesar applicationoftwinscrewextrusioninthemanufactureofcocrystalspartifourcasestudies
AT sawrobert applicationoftwinscrewextrusioninthemanufactureofcocrystalspartifourcasestudies
AT nagapudikarthik applicationoftwinscrewextrusioninthemanufactureofcocrystalspartifourcasestudies
AT alvareznunezfernando applicationoftwinscrewextrusioninthemanufactureofcocrystalspartifourcasestudies