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Simultaneous In Vitro Characterisation of DNA Deaminase Function and Associated DNA Repair Pathways

During immunoglobulin (Ig) diversification, activation-induced deaminase (AID) initiates somatic hypermutation and class switch recombination by catalysing the conversion of cytosine to uracil. The synergy between AID and DNA repair pathways is fundamental for the introduction of mutations, however...

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Detalles Bibliográficos
Autores principales:	Franchini, Don-Marc, Incorvaia, Elisabetta, Rangam, Gopinath, Coker, Heather A., Petersen-Mahrt, Svend K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857227/ https://www.ncbi.nlm.nih.gov/pubmed/24349193 http://dx.doi.org/10.1371/journal.pone.0082097

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