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Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population
H. pylori persistent infection induces chronic gastritis and is associated with peptic ulcer disease and gastric carcinoma development. The severity of these diseases is related to human’s genetic diversity, H. pylori genetic variability and environmental factors. To identify the prevalence of histo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857243/ https://www.ncbi.nlm.nih.gov/pubmed/24349327 http://dx.doi.org/10.1371/journal.pone.0082646 |
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author | Alaoui Boukhris, Samia Amarti, Afaf El Rhazi, Karima El Khadir, Mounia Benajah, Dafr-Allah Ibrahimi, Sidi Adil Nejjari, Chakib Mahmoud, Mustapha Souleimani, Abdellah Bennani, Bahia |
author_facet | Alaoui Boukhris, Samia Amarti, Afaf El Rhazi, Karima El Khadir, Mounia Benajah, Dafr-Allah Ibrahimi, Sidi Adil Nejjari, Chakib Mahmoud, Mustapha Souleimani, Abdellah Bennani, Bahia |
author_sort | Alaoui Boukhris, Samia |
collection | PubMed |
description | H. pylori persistent infection induces chronic gastritis and is associated with peptic ulcer disease and gastric carcinoma development. The severity of these diseases is related to human’s genetic diversity, H. pylori genetic variability and environmental factors. To identify the prevalence of histo-pathological damages caused by H. pylori infection in Moroccan population, and to determine their association to H. pylori genotypes, a prospective study has been conducted during 3 years on patients attending the gastroenterology department of Hassan II University Hospital (CHU) of Fez, Morocco. A total of 801 Moroccan adults’ patients were recruited; H. pylori was diagnosed and genotyped by PCR in biopsy specimens and histological exam was performed. We found a high rate of glandular atrophy. Chronic inflammation, neutrophil activity and glandular atrophy showed statistically significant association with H. pylori infection. However, intestinal metaplasia was inversely associated to this infection and no association was observed with gastric cancer cases. A statistically significant association was found between intestinal metaplasia and vacAs1 and vac Am1 genotypes in patients aged 50 years and more but not in younger. This last genotype is also associated to gastric cancer. In this study, gastric cancer showed no significant association with H. pylori. Further studies are warranted to determine the role of other etiological agents such as Epstein-Barr virus, human papillomavirus and possibly environmental and dietetic factors in the occurrence of this pathology. |
format | Online Article Text |
id | pubmed-3857243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38572432013-12-13 Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population Alaoui Boukhris, Samia Amarti, Afaf El Rhazi, Karima El Khadir, Mounia Benajah, Dafr-Allah Ibrahimi, Sidi Adil Nejjari, Chakib Mahmoud, Mustapha Souleimani, Abdellah Bennani, Bahia PLoS One Research Article H. pylori persistent infection induces chronic gastritis and is associated with peptic ulcer disease and gastric carcinoma development. The severity of these diseases is related to human’s genetic diversity, H. pylori genetic variability and environmental factors. To identify the prevalence of histo-pathological damages caused by H. pylori infection in Moroccan population, and to determine their association to H. pylori genotypes, a prospective study has been conducted during 3 years on patients attending the gastroenterology department of Hassan II University Hospital (CHU) of Fez, Morocco. A total of 801 Moroccan adults’ patients were recruited; H. pylori was diagnosed and genotyped by PCR in biopsy specimens and histological exam was performed. We found a high rate of glandular atrophy. Chronic inflammation, neutrophil activity and glandular atrophy showed statistically significant association with H. pylori infection. However, intestinal metaplasia was inversely associated to this infection and no association was observed with gastric cancer cases. A statistically significant association was found between intestinal metaplasia and vacAs1 and vac Am1 genotypes in patients aged 50 years and more but not in younger. This last genotype is also associated to gastric cancer. In this study, gastric cancer showed no significant association with H. pylori. Further studies are warranted to determine the role of other etiological agents such as Epstein-Barr virus, human papillomavirus and possibly environmental and dietetic factors in the occurrence of this pathology. Public Library of Science 2013-12-09 /pmc/articles/PMC3857243/ /pubmed/24349327 http://dx.doi.org/10.1371/journal.pone.0082646 Text en © 2013 Alaoui Boukhris et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Alaoui Boukhris, Samia Amarti, Afaf El Rhazi, Karima El Khadir, Mounia Benajah, Dafr-Allah Ibrahimi, Sidi Adil Nejjari, Chakib Mahmoud, Mustapha Souleimani, Abdellah Bennani, Bahia Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population |
title |
Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population |
title_full |
Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population |
title_fullStr |
Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population |
title_full_unstemmed |
Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population |
title_short |
Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population |
title_sort | helicobacter pylori genotypes associated with gastric histo-pathological damages in a moroccan population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857243/ https://www.ncbi.nlm.nih.gov/pubmed/24349327 http://dx.doi.org/10.1371/journal.pone.0082646 |
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