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A Change in Configuration of the Calmodulin-KCNQ Channel Complex Underlies Ca(2+)-Dependent Modulation of KCNQ Channel Activity
All subtypes of KCNQ channel subunits (KCNQ1-5) require calmodulin as a co-factor for functional channels. It has been demonstrated that calmodulin plays a critical role in KCNQ channel trafficking as well as calcium-mediated current modulation. However, how calcium-bound calmodulin suppresses the M...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857245/ https://www.ncbi.nlm.nih.gov/pubmed/24349250 http://dx.doi.org/10.1371/journal.pone.0082290 |