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Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study

BACKGROUND: Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan. METHODS: The case-control study subjects were obt...

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Autores principales: Chang, Yen-Liang, Hung, Shih-Han, Ling, Wells, Lin, Herng-Ching, Li, Hsien-Chang, Chung, Shiu-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857285/
https://www.ncbi.nlm.nih.gov/pubmed/24349404
http://dx.doi.org/10.1371/journal.pone.0082952
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author Chang, Yen-Liang
Hung, Shih-Han
Ling, Wells
Lin, Herng-Ching
Li, Hsien-Chang
Chung, Shiu-Dong
author_facet Chang, Yen-Liang
Hung, Shih-Han
Ling, Wells
Lin, Herng-Ching
Li, Hsien-Chang
Chung, Shiu-Dong
author_sort Chang, Yen-Liang
collection PubMed
description BACKGROUND: Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan. METHODS: The case-control study subjects were obtained from the Taiwanese Longitudinal Health Insurance Database 2000. We included 51,093 subjects with stroke as cases and randomly selected 153,279 controls (3 controls per case) in this study.Separate conditional logistic regression analyses were used to calculate the odds ratio (OR) for having been previously diagnosed with IDA between cases and controls.We further analyzed the association between stroke and IDA by stroke subtype. RESULTS: Results showed that 3,685 study subjects (1.81%) had been diagnosed with IDA prior to the index date; of those subjects, 1,268 (2.48%) were cases and 2,417 (1.58%) were controls (p<0.001). Conditional logistic regression shows that the OR of having previously received an IDA diagnosis among cases was 1.49 (95% CI: 1.39~1.60; p < 0.01) that of controls after adjusting for monthly income, geographic region, hypertension, diabetes, coronary heart disease, atrial fibrillation, heart failure, hyperlipidemia, tobacco use disorder, and alcohol abuse/alcohol dependency syndrome. Furthermore, the adjusted OR of prior IDA for cases with ischemic stroke was found to be 1.45 (95% CI: 1.34~1.58) compared to controls. However, we did not find any significant relationship between IDA and subarachnoid/intracerebral hemorrhage even adjusting for other confounding factors (OR=1.17, 95% CI=0.97~1.40). CONCLUSION: There is a significant association between prior IDA and ischemic stroke.
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spelling pubmed-38572852013-12-13 Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study Chang, Yen-Liang Hung, Shih-Han Ling, Wells Lin, Herng-Ching Li, Hsien-Chang Chung, Shiu-Dong PLoS One Research Article BACKGROUND: Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan. METHODS: The case-control study subjects were obtained from the Taiwanese Longitudinal Health Insurance Database 2000. We included 51,093 subjects with stroke as cases and randomly selected 153,279 controls (3 controls per case) in this study.Separate conditional logistic regression analyses were used to calculate the odds ratio (OR) for having been previously diagnosed with IDA between cases and controls.We further analyzed the association between stroke and IDA by stroke subtype. RESULTS: Results showed that 3,685 study subjects (1.81%) had been diagnosed with IDA prior to the index date; of those subjects, 1,268 (2.48%) were cases and 2,417 (1.58%) were controls (p<0.001). Conditional logistic regression shows that the OR of having previously received an IDA diagnosis among cases was 1.49 (95% CI: 1.39~1.60; p < 0.01) that of controls after adjusting for monthly income, geographic region, hypertension, diabetes, coronary heart disease, atrial fibrillation, heart failure, hyperlipidemia, tobacco use disorder, and alcohol abuse/alcohol dependency syndrome. Furthermore, the adjusted OR of prior IDA for cases with ischemic stroke was found to be 1.45 (95% CI: 1.34~1.58) compared to controls. However, we did not find any significant relationship between IDA and subarachnoid/intracerebral hemorrhage even adjusting for other confounding factors (OR=1.17, 95% CI=0.97~1.40). CONCLUSION: There is a significant association between prior IDA and ischemic stroke. Public Library of Science 2013-12-09 /pmc/articles/PMC3857285/ /pubmed/24349404 http://dx.doi.org/10.1371/journal.pone.0082952 Text en © 2013 Chang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chang, Yen-Liang
Hung, Shih-Han
Ling, Wells
Lin, Herng-Ching
Li, Hsien-Chang
Chung, Shiu-Dong
Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study
title Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study
title_full Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study
title_fullStr Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study
title_full_unstemmed Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study
title_short Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study
title_sort association between ischemic stroke and iron-deficiency anemia: a population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857285/
https://www.ncbi.nlm.nih.gov/pubmed/24349404
http://dx.doi.org/10.1371/journal.pone.0082952
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