Cargando…
Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study
BACKGROUND: Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan. METHODS: The case-control study subjects were obt...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857285/ https://www.ncbi.nlm.nih.gov/pubmed/24349404 http://dx.doi.org/10.1371/journal.pone.0082952 |
_version_ | 1782295144101314560 |
---|---|
author | Chang, Yen-Liang Hung, Shih-Han Ling, Wells Lin, Herng-Ching Li, Hsien-Chang Chung, Shiu-Dong |
author_facet | Chang, Yen-Liang Hung, Shih-Han Ling, Wells Lin, Herng-Ching Li, Hsien-Chang Chung, Shiu-Dong |
author_sort | Chang, Yen-Liang |
collection | PubMed |
description | BACKGROUND: Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan. METHODS: The case-control study subjects were obtained from the Taiwanese Longitudinal Health Insurance Database 2000. We included 51,093 subjects with stroke as cases and randomly selected 153,279 controls (3 controls per case) in this study.Separate conditional logistic regression analyses were used to calculate the odds ratio (OR) for having been previously diagnosed with IDA between cases and controls.We further analyzed the association between stroke and IDA by stroke subtype. RESULTS: Results showed that 3,685 study subjects (1.81%) had been diagnosed with IDA prior to the index date; of those subjects, 1,268 (2.48%) were cases and 2,417 (1.58%) were controls (p<0.001). Conditional logistic regression shows that the OR of having previously received an IDA diagnosis among cases was 1.49 (95% CI: 1.39~1.60; p < 0.01) that of controls after adjusting for monthly income, geographic region, hypertension, diabetes, coronary heart disease, atrial fibrillation, heart failure, hyperlipidemia, tobacco use disorder, and alcohol abuse/alcohol dependency syndrome. Furthermore, the adjusted OR of prior IDA for cases with ischemic stroke was found to be 1.45 (95% CI: 1.34~1.58) compared to controls. However, we did not find any significant relationship between IDA and subarachnoid/intracerebral hemorrhage even adjusting for other confounding factors (OR=1.17, 95% CI=0.97~1.40). CONCLUSION: There is a significant association between prior IDA and ischemic stroke. |
format | Online Article Text |
id | pubmed-3857285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38572852013-12-13 Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study Chang, Yen-Liang Hung, Shih-Han Ling, Wells Lin, Herng-Ching Li, Hsien-Chang Chung, Shiu-Dong PLoS One Research Article BACKGROUND: Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan. METHODS: The case-control study subjects were obtained from the Taiwanese Longitudinal Health Insurance Database 2000. We included 51,093 subjects with stroke as cases and randomly selected 153,279 controls (3 controls per case) in this study.Separate conditional logistic regression analyses were used to calculate the odds ratio (OR) for having been previously diagnosed with IDA between cases and controls.We further analyzed the association between stroke and IDA by stroke subtype. RESULTS: Results showed that 3,685 study subjects (1.81%) had been diagnosed with IDA prior to the index date; of those subjects, 1,268 (2.48%) were cases and 2,417 (1.58%) were controls (p<0.001). Conditional logistic regression shows that the OR of having previously received an IDA diagnosis among cases was 1.49 (95% CI: 1.39~1.60; p < 0.01) that of controls after adjusting for monthly income, geographic region, hypertension, diabetes, coronary heart disease, atrial fibrillation, heart failure, hyperlipidemia, tobacco use disorder, and alcohol abuse/alcohol dependency syndrome. Furthermore, the adjusted OR of prior IDA for cases with ischemic stroke was found to be 1.45 (95% CI: 1.34~1.58) compared to controls. However, we did not find any significant relationship between IDA and subarachnoid/intracerebral hemorrhage even adjusting for other confounding factors (OR=1.17, 95% CI=0.97~1.40). CONCLUSION: There is a significant association between prior IDA and ischemic stroke. Public Library of Science 2013-12-09 /pmc/articles/PMC3857285/ /pubmed/24349404 http://dx.doi.org/10.1371/journal.pone.0082952 Text en © 2013 Chang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chang, Yen-Liang Hung, Shih-Han Ling, Wells Lin, Herng-Ching Li, Hsien-Chang Chung, Shiu-Dong Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study |
title | Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study |
title_full | Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study |
title_fullStr | Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study |
title_full_unstemmed | Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study |
title_short | Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study |
title_sort | association between ischemic stroke and iron-deficiency anemia: a population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857285/ https://www.ncbi.nlm.nih.gov/pubmed/24349404 http://dx.doi.org/10.1371/journal.pone.0082952 |
work_keys_str_mv | AT changyenliang associationbetweenischemicstrokeandirondeficiencyanemiaapopulationbasedstudy AT hungshihhan associationbetweenischemicstrokeandirondeficiencyanemiaapopulationbasedstudy AT lingwells associationbetweenischemicstrokeandirondeficiencyanemiaapopulationbasedstudy AT linherngching associationbetweenischemicstrokeandirondeficiencyanemiaapopulationbasedstudy AT lihsienchang associationbetweenischemicstrokeandirondeficiencyanemiaapopulationbasedstudy AT chungshiudong associationbetweenischemicstrokeandirondeficiencyanemiaapopulationbasedstudy |