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Improved Mitochondrial Function Underlies the Protective Effect of Pirfenidone against Tubulointerstitial Fibrosis in 5/6 Nephrectomized Rats

Dysfunctional mitochondria participate in the progression of chronic kidney disease (CKD). Pirfenidone is a newly identified anti-fibrotic drug. However, its mechanism remains unclear. Mitochondrial dysfunction is an early event that occurs prior to the onset of renal fibrosis. In this context, we i...

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Detalles Bibliográficos
Autores principales:	Chen, Jun-Feng, Liu, Hong, Ni, Hai-Feng, Lv, Lin-Li, Zhang, Ming-Hui, Zhang, Ai-Hua, Tang, Ri-Ning, Chen, Ping-Sheng, Liu, Bi-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857290/ https://www.ncbi.nlm.nih.gov/pubmed/24349535 http://dx.doi.org/10.1371/journal.pone.0083593

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