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Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA

Cytoplasmic viral RNA and DNA are recognized by RIG-I-like receptors and DNA sensors that include DAI, IFI16, DDX41, and cGAS. The RNA and DNA sensors evoke innate immune responses through the IPS-1 and STING adaptors. IPS-1 and STING activate TBK1 kinase. TBK1 is phosphorylated in its activation lo...

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Detalles Bibliográficos
Autores principales:	Suzuki, Takayuki, Oshiumi, Hiroyuki, Miyashita, Moeko, Aly, Hussein Hassan, Matsumoto, Misako, Seya, Tsukasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857317/ https://www.ncbi.nlm.nih.gov/pubmed/24349538 http://dx.doi.org/10.1371/journal.pone.0083639

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