HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

Histone deacetylases (HDACs) and acetyltransferases have important roles in the regulation of protein acetylation, chromatin dynamics and the DNA damage response. Here, we show in human colon cancer cells that dietary isothiocyanates (ITCs) inhibit HDAC activity and increase HDAC protein turnover wi...

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Detalles Bibliográficos
Autores principales: Rajendran, Praveen, Kidane, Ariam I., Yu, Tian-Wei, Dashwood, Wan-Mohaiza, Bisson, William H., Löhr, Christiane V., Ho, Emily, Williams, David E., Dashwood, Roderick H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857341/
https://www.ncbi.nlm.nih.gov/pubmed/23770684
http://dx.doi.org/10.4161/epi.24710

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